中南医学科学杂志2025，Vol.53Issue(3)：426-430,5.DOI:10.15972/j.cnki.43-1509/r.2025.03.011
不同病理分型肺腺癌CT征象及其与血清肿瘤标志物水平、EGFR基因突变的关系
CT features of lung adenocarcinoma with different pathological subtypes and their correlation with serum tumor marker levels and EGFR gene mutations
摘要
Abstract
Aim To investigate the CT features of different pathological subtypes of lung adenocarcinoma and their correlation with serum tumor markers carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125)levels,and epidermal growth factor receptor(EGFR)gene mutations.Methods 80 patients with lung adenocarcinoma in our hospital were divided into pre-invasive group(19 cases),microinvasive group(22 cases),and invasive group(39 cases)based on their surgical and pathologi-cal results.All patients underwent CT scanning before surgery to analyze the CT features of different pathological subtypes of lung ad-enocarcinoma.The expression levels of serum tumor markers CEA and CA125 in lung adenocarcinoma under different CT signs,as well as CT features of patients carrying EGFR gene mutation were compared.Results The proportion of lesion lung interface blur,lobulation sign,spiculation sign,vacuolar sign,and nodule diameter in patients with lung adenocarcinoma followed an order of the invasive group＞microinvasive group＞pre-invasive group(P＜0.05);The proportion of pure ground glass nodules was in the order of invasive group＜microinvasive group＜pre-invasive group(P＜0.05);The proportion of pleural indentation sign and air bronchogram sign in the invasive group were higher than those in the microinvasive group and pre-invasive group(P＜0.05).The serum tumor markers CEA and CA125 levels were higher in patients with CT signs of lobulation,vacuolar sign,and nodule diameter ≥ 20 mm com-pared with the patients without lobulation sign,vacuolar sign,and nodule diameter＜20 mm(P＜0.05).Out of 80 patients with lung adenocarcinoma,60 cases(75.00％)developed EGFR gene mutations,with 19Del and L858R mutations being the main types of mu-tations.The proportion of pure ground glass nodules in EGFR mutant patients was higher than that in EGFR wild-type patients(P＜0.05).Conclusion CT signs can reflect the invasion degree of lung adenocarcinoma to a certain extent,and its imaging manifes-tations are closely related with serum tumor marker CEA and CA125 expression levels,with a higher EGFR gene mutation rate among patients with pure ground-glass nodules.关键词
肺腺癌/病理分型/CT征象/肿瘤标志物/表皮生长因子受体Key words
lung adenocarcinoma/pathological subtype/CT features/tumor markers/EGFR分类
临床医学引用本文复制引用
倪玉宝,卢金山,陈健..不同病理分型肺腺癌CT征象及其与血清肿瘤标志物水平、EGFR基因突变的关系[J].中南医学科学杂志,2025,53(3):426-430,5.基金项目
安徽省卫生健康委科研项目(AHWJ2021b005) （AHWJ2021b005）
