中南医学科学杂志2025，Vol.53Issue(3)：470-472,3.DOI:10.15972/j.cnki.43-1509/r.2025.03.022
血尿酸及CYR61与老年糖尿病患者骨密度、骨代谢的相关性
Correlation between serum uric acid,CYR61 and bone mineral density,bone metabolism in elderly patients with diabetes
摘要
Abstract
Aim To investigate the correlation between serum uric acid,cysteine-rich protein 61(CYR61)and bone mineral density,bone metabolism in elderly patients with diabetes.Methods A total of 232 elderly diabetic patients were divided into a hyperuricemia group(n=109)and a normal uric acid group(n=123)according to serum uric acid levels.Serum uric acid,CYR61,lumbar spine(L1-L4)bone mineral density,femoral neck bone mineral density,total hip bone mineral density and bone me-tabolism markers(procollagen type Ⅰ N-terminal propeptide(PINP),β-C-terminal telopeptide of type Ⅰ collagen(β-CTX),25-hydroxyvitamin D3(25-(OH)D3),osteocalcin(OCN))were measured and analyzed.Results The hyperuricemia group had higher serum uric acid but lower CYR61 levels compared to the normal group(P＜0.05).L1-L4 and total hip bone mineral density were lower in hyperuricemia group(P＜0.05).PINP,β-CTX,25-(OH)D3 and OCN were lower in hyperuricemia group(P＜0.05).Pearson analysis showed serum uric acid was negatively correlated with total hip BMD,L1-L4 bone mineral density,25-(OH)D3,PINP,β-CTX and OCN(P＜0.05).CYR61 was positively correlated with total hip BMD,L1-L4 bone mineral density,PINP,25-(OH)D3 and OCN,but negatively correlated with β-CTX(P＜0.05).Conclusion Serum uric acid and CYR61 are significantly correlated with bone mineral density and bone metabolism in elderly diabetic patients.关键词
血尿酸/CYR61/老年/糖尿病/骨密度/骨代谢Key words
serum uric acid/CYR61/elderly/diabetes/bone mineral density/bone metabolism分类
医药卫生引用本文复制引用
胡海鹰,庾利,陈琦..血尿酸及CYR61与老年糖尿病患者骨密度、骨代谢的相关性[J].中南医学科学杂志,2025,53(3):470-472,3.基金项目
四川省干部保健科研课题(川干研2019-114) （川干研2019-114）
