中南医学科学杂志2025，Vol.53Issue(3)：496-499,4.DOI:10.15972/j.cnki.43-1509/r.2025.03.029
免疫球蛋白联用干扰素对EV71型感染致重症手足口病患儿免疫功能及炎症因子的影响
Effects of immunoglobulin combined with interferon on immune function and inflammatory factors in children with severe hand-foot-mouth disease caused by EV71 infection
摘要
Abstract
Aim To investigate the effects of human immunoglobulin combined with interferon on immune function and in-flammatory factors in children with severe hand-foot-mouth disease caused by enterovirus 71(EV71)infection.Methods 120 children with severe EV71-induced hand-foot-mouth disease in our hospital were selected as the study population,and were divided into interferon group and combined group by alottery method.Both groups received conventional treatments such as anti-infection,fever reduction,regulation of water and electrolyte imbalance,and fluid replacement.The interferon group received nebulized interferon inhalation on the basis of conventional treatment,while the combined group received combined treatment with human immunoglobulin on the basis of interferon group.The levels of peripheral inflammatory cytokines interleukin-6(IL-6),IL-8,endothelin-1(ET-1),interferon γ-inducible protein-10(IP-10),and immune function indicators(CD3+,CD4+,CD8+,CD4+/CD8+)before and after treatment between the two groups were compared.The clinical efficacy,symptom disappearance time,hospitalization time,and inci-dence of adverse reactions between the two groups were compared.Results After treatment,the levels of IL-6,IL-8,ET-1,IP-10,and CD8+values in both groups were decreased,and the combined group was lower than the interferon group(P＜0.05);Both groups showed an increase in CD3+,CD4+,and CD4+/CD8+,with the combined group being higher than the interferon group(P＜0.05).The total effective rate of the combined group was higher than that of the interferon group(P＜0.05),and the time for symptom disappearance and hospitalization were shorter than those of the interferon group(P＜0.05).There was no significant difference in adverse reactions between the two groups(P＞0.05).Conclusion Human immunoglobulin combined with interferon can improve immune function,reduce inflammatory factors and enhance clinical efficacy in children with severe hand-foot-mouth disease caused by EV71 infection.关键词
免疫球蛋白/干扰素/EV71/手足口病/免疫功能/炎症因子Key words
immunoglobulin/interferon/EV71/hand-foot-mouth disease/immune function/inflammatory factors分类
医药卫生引用本文复制引用
刘丽敏,刘召璞,王云茹,郝现伟..免疫球蛋白联用干扰素对EV71型感染致重症手足口病患儿免疫功能及炎症因子的影响[J].中南医学科学杂志,2025,53(3):496-499,4.基金项目
邢台市重点研发计划项目(ZC30701) （ZC30701）
