中南医学科学杂志2025，Vol.53Issue(3)：509-512,4.DOI:10.15972/j.cnki.43-1509/r.2025.03.032
依达拉奉右莰醇辅助治疗对基底动脉穿支型脑梗死患者微循环及血清NO、SOD水平的影响
Effects of Edaravone and borneol as adjuvant therapy on microcirculation and serum NO and SOD levels in patients with basilar artery perforator cerebral infarction
摘要
Abstract
Aim To investigate the effects of Edaravone and borneol as adjuvant therapy on microcirculation and serum nitric oxide(NO),and superoxide dismutase(SOD)levels in patients with basilar artery perforator cerebral infarction.Methods A total of 96 patients with basilar artery perforator cerebral infarction were randomly divided into recombinant tissue-type plasminogen ac-tivator(rt-PA)group and combined group.The rt-PA group was treated with rt-PA,while the combined group received Edaravone and borneol as adjuvant therapy on the basis of rt-PA treatment.Clinical efficacy and adverse reactions were compared between the two groups.Hemorheological indicators(plasma viscosity,high-shear whole blood viscosity,platelet adhesion rate),NO and SOD levels,national institutes of health stroke scale(NIHSS)scores,and modified Barthel index(MBI)scores were compared before and after treatment between the two groups.Results There were no statistically significant differences in clinical efficacy and adverse reactions between the two groups(P＞0.05).After treatment,plasma viscosity,high-shear whole blood viscosity,platelet adhesion rate,NO levels,and NIHSS scores were decreased in both groups(P＜0.05),with the combined group being lower than the rt-PA group(P＜0.05);SOD levels and MBI scores were increased in both groups(P＜0.05),with the combined group being higher than the rt-PA group(P＜0.05).Conclusion Edaravone and borneol as adjuvant therapy can improve microcirculation in patients with basilar artery perforator cerebral infarction,regulate serum NO and SOD levels,reduce systemic oxidative stress response,and promote recovery of neurological function and daily living abilities.关键词
脑梗死/基底动脉穿支型/依达拉奉/右莰醇/微循环/NO/SODKey words
cerebral infarction/basilar artery perforator/Edaravone/borneol/microcirculation/NO/SOD分类
医药卫生引用本文复制引用
丁建,王海亮,宋蕊楠,崔二平,刘洁,杨丽华..依达拉奉右莰醇辅助治疗对基底动脉穿支型脑梗死患者微循环及血清NO、SOD水平的影响[J].中南医学科学杂志,2025,53(3):509-512,4.基金项目
沧州市科技计划自筹项目(222106037) （222106037）
