中南医学科学杂志2025，Vol.53Issue(3)：531-534,4.DOI:10.15972/j.cnki.43-1509/r.2025.03.038
瑞马唑仑联合纳布啡用于消化内镜检查镇静的临床价值及其对血流动力学的影响
The clinical value and hemodynamic effects of remimazolam combined with nalbuphine in se-dation for digestive endoscopy examination
摘要
Abstract
Aim To evaluate the clinical value and hemodynamics effects of remimazolam combined with nalbuphine in se-dation for digestive endoscopy examination.Methods A total of 98 patients who underwent painless digestive endoscopy in our hospital were randomly divided into the remimazolam combined group(remimazolam combined with nalbuphine)and the propofol com-bined group(propofol combined with nalbuphine).The heart rate(HR),mean arterial pressure(MAP),respiratory rate(RR)and saturation of pulse oxygen(SpO2)of two groups before examination(T0),at the end of gastroscopy(T1),at the end of colonos-copy(T2),and at awakening(T3)were compared.The awakening time and intervals between additional medication does for two groups were recorded.The mini-mental state examination(MMSE)was used to evaluate the cognitive function of two groups,and the visual analogue scale was used to assess the satisfaction and willingness to re-examine of both groups.The incidence of adverse reac-tions in two groups were recorded.Results At T1,T2,and T3,MAP,HR,RR,and SpO2 in both groups were decreased com-pared to T0(P＜0.05);And the propofol combined group was lower than the remimazolam combined group(P＜0.05).Compared with the propofol combined group,the remimazolam combined group had a shorter postoperative recovery time and a shorter interval be-tween the second and third additional medication does(P＜0.05).There was no statistically significant difference(P＞0.05)in cog-nitive function MMSE scores at different time points,satisfaction,and willingness to re-examine between the two groups of patients.The incidence of injection pain,respiratory depression,and hypotension in the remimazolam combined group were lower than those in the propofol combined group(P＜0.05).Conclusion The combination of remimazolam and nalbuphine is used for digestive en-doscopy examination sedation,which has the advantage of stable hemodynamic characteristics,short recovery time,and low incidence of adverse reactions.Its clinical application value is high.关键词
瑞马唑仑/纳布啡/消化内镜检查/镇静/血流动力学Key words
remimazolam/nalbuphine/digestive endoscopy examination/sedation/hemodynamics分类
医药卫生引用本文复制引用
王勇,孟祥云,张天虹,任晓荣,刘旭升..瑞马唑仑联合纳布啡用于消化内镜检查镇静的临床价值及其对血流动力学的影响[J].中南医学科学杂志,2025,53(3):531-534,4.基金项目
第九八二医院科研任务书(院内课题)(DJBE2024-006) （院内课题）
