中国海洋大学学报（自然科学版）2025，Vol.55Issue(6)：75-89,15.DOI:10.16441/j.cnki.hdxb.20230345
氢化阿托酸改性壳聚糖/氧化葡甘露聚糖多功能水凝胶的制备与表征
Preparation and Characterization of Multifunctional Hydrogels Based on Modified Chitosan/Oxidized Glucomannan
摘要
Abstract
To develop multifunctional hydrogels possessing excellent biocompatibility,antibacterial ac-tivity,and antioxidant property,as well as suitable adhesion and degradability,we innovatively modi-fied chitosan(CS)by using hydrotropic acid(HA)for obtaining HA-modified CS(CSHA)in this work.FTIR and UV-Vis results showed that CSHA with a grafting degree of 26.64％was successfully synthesized via the amide reaction.Compared to that of CS,the crystallinity of CSHA decreased and its solubility was improved.Simultaneously,oxidized glucomannan(OGM)with an oxidation degree of 24.07％was acquired through the periodate oxidation method.Based on the above outcomes,four kinds of CSHA/OGM hydrogels(CH-OG-HGs)were successfully constructed via the Schiff base reaction,and their physicochemical and biological properties were studied.Experimental results revealed that CH-OG-HGs had a short period of gelation time(＜70 s),a maximum equilibrium swelling rate of 17.54％,a maximum adhesion strength of 1 400 kPa,and a high degradation rate(＞99.39％)within 30 days.Rheological test results showed that CH-OG-HGs had shear thinning characteristics,self-heal-ing property,and appropriate mechanical strength.SEM results indicated that CH-OG-HGs possessed interconnected three-dimensional network structures.CH-OG-HGs had much low cytotoxicity to L929 and HSF cells,and their hemolysis rates were less than 5％,which is in accord with the standards of bi-omedical materials.Furthermore,CH-OG-HGs exhibited a remarkable inhibition rate(up to 95.94％)against both E.coli and S.aureus,and different radical scavenging ratios of around 90％for ABTS+·and 40％for·OH.In summary,CH-OG-HGs not only possessed suitable mechanical strength,adhe-sive strength,swelling property,and low toxicity,but also had excellent antibacterial,antioxidant,in-jectable,degradable,and self-recovery properties,which collectively highlights their enormous potential for application in various biomedical fields such as wound dressings,drug release carriers,and tissue en-gineering materials.关键词
壳聚糖/葡甘露聚糖/水凝胶/抗氧化/自愈性Key words
chitosan/glucomannan/hydrogel/antioxidation/self-recovery分类
化学工程引用本文复制引用
杨梦,党奇峰,牛嗣玉,王世云,赵燕,苏洁瑜,桑丰,刘成圣..氢化阿托酸改性壳聚糖/氧化葡甘露聚糖多功能水凝胶的制备与表征[J].中国海洋大学学报（自然科学版）,2025,55(6):75-89,15.基金项目
国家自然科学基金项目(31400812)资助 Supported by the National Nature Science Foundation of China(31400812) （31400812）
