日用化学工业（中英文）2025，Vol.55Issue(5)：616-624,9.DOI:10.3969/j.issn.2097-2806.2025.05.010
基于网络药理学探究大花红景天改善皮肤毛细血管扩张症机制
Elucidating the potential mechanism of Rhodiola crenulata on improving skin telangiectasia based on network pharmacology
摘要
Abstract
Based on network pharmacology and experimental verification,the improvement of Rhodiola cernulata (R.crenulata)on skin telangiectasia was investigated to provide scientific basis for its comprehensive utilization in cosmetics,food and other fields.The active ingredients of R.cernulata were retrieved from SymMap and TCMIP database.Targets related to R.crenulata and skin telangiectasia were predicted using Swiss Target Prediction and Genecards database.The interactions between proteins were analyzed using String and the KEGG signaling pathways enrichment analysis were performed further.Finally,in vitro cell experiments were used to preliminarily verify the improvement of R.crenulate on skin telangiectasia.A total of 14 active ingredients of R.crenulata are selected to obtain 253 corresponding targets and 2646 targets related to skin telangiectasia,of which 164 are intersection targets.The results of KEGG pathway enrichment analysis show that R.crenulata may play a role in inhibiting skin telangiectasia through Ras,VEGF,HIF-1,and other signaling pathways related to angiogenesis.In vitro cell experiment results show that R.crenulata extract can significantly inhibit the secretion of VEGF in keratinocytes(HaCaT)induced by TNF-α,and it further inhibit the proliferation,migration and formation of tubular structures of human umbilical can vein endothelial cells(HUVEC)induced by VEGF,which reflect the potential value of R.crenulata in treating skin telangiectasia.关键词
大花红景天/网络药理/毛细血管扩张/血管生成Key words
Rhodiola cernulata/network pharmacology/telangiectasia/angiogenesis分类
化学工程引用本文复制引用
王斌雅,杨杨,权强华,安全,杨成,赵炳天..基于网络药理学探究大花红景天改善皮肤毛细血管扩张症机制[J].日用化学工业（中英文）,2025,55(5):616-624,9.基金项目
国家自然科学基金青年科学基金项目(22208121) （22208121）
江苏省自然科学基金青年项目(BK20221069) （BK20221069）
