生物医学工程研究2025，Vol.44Issue(2)：112-118,7.DOI:10.19529/j.cnki.1672-6278.2025.02.07
多点注射Fe3O4辅助肝组织微波消融的有限元分析
Finite element analysis of micro wave ablation of liver tissue assisted by multi-site injection of Fe3O4
摘要
Abstract
To investigate the effect of multi-point injection of Fe3O4 nanoparticles on the ablation results,we constructed a mathe-matical model of Fe3O4 nanoparticle-assisted microwave ablation(MWA)in liver tissue by COMSOL Multiphysics 6.1 software.First-ly,the effect of the number of injection domains(2～7)on the ablation zone of MWA was investigated when the injection volume was fixed,and after that,the effect of different injection radii(1～4.49 mm)on the ablation zone of MWA was investigated when the num-ber of injection domains was fixed.The results showed that when the injection volume was fixed at 2.45 GHz and 15 W,the number of injection fields was 6,7 to achieve better ablation effect.When the number of injection fields was 6,the injection radius was 3.62 mm,the ideal ablation effect was achieved.The transverse diameter of the ablation zone increased by 5.77 mm,the volume increased by 68.75％,and the roundness increased from 0.786 to 0.885.When the number of injection fields was 7,the radius of the injection field was 3.49 mm,the ablation effect was better,the transverse diameter of the ablation zone was increased by 3.52 mm,the volume was increased by 61.98％,and the roundness was increased from 0.786 to 0.869.The research indicates that adding Fe3O4 nanoparticles to MWA can increase the sphericity of the ablation zone,which is more suitable for the treatment of spheroidal tumors.关键词
肿瘤/微波消融/Fe3O4/多点注射/磁流体热疗Key words
Tumor/Microwave ablation/Fe3O4/Multi-site injection/Magnetic fluid hyperthermia分类
基础医学引用本文复制引用
乔永琴,南群..多点注射Fe3O4辅助肝组织微波消融的有限元分析[J].生物医学工程研究,2025,44(2):112-118,7.基金项目
国家自然科学基金项目(31771021,11832003). （31771021,11832003）
