生物医学工程研究2025，Vol.44Issue(2)：125-134,10.DOI:10.19529/j.cnki.1672-6278.2025.02.09
纳米酶级联催化系统的合理设计及其癌症治疗应用
Rational design and applications of nanozyme cascade catalytic systems in cancer therapy
贾修娜 1魏绪华 2李敬 1汪尔康1
作者信息
- 1. 中国科学院长春应用化学研究所电分析化学国家重点实验室,长春 130022
- 2. 肥城市人民医院,肥城 271699
- 折叠
摘要
Abstract
Nanozymes catalyzes the conversion of tumor-associated substances into toxic reactive oxygen species(ROS),which induce oxidative stress and promote cancer cell death.However,in the complex tumor microenvironment,factors such as the design,activity,reaction substrates,and the microenvironment all impact the efficiency of ROS generation.To address these challenges,relat-ed research has focused on optimizing active factors and developing nanozyme cascade catalytic systems that can trigger multiple cascade processes within tumors to efficiently and stably generate more therapeutic substances while minimizing side effects.This paper discus-ses effective strategies for the design of cascade catalytic systems,summarizes representative cases of nanozyme cascade catalytic sys-tems in cancer therapy,and reveals their potential catalytic mechanisms.Finally,the paper outline the challenges faced by these sys-tems in biomedical applications and discuss their future prospects.关键词
纳米酶/级联催化系统/合理设计/级联催化反应/癌症治疗Key words
Nanozymes/Cascade catalytic systems/Rational design/Cascade catalytic reactions/Cancer therapy分类
基础医学引用本文复制引用
贾修娜,魏绪华,李敬,汪尔康..纳米酶级联催化系统的合理设计及其癌症治疗应用[J].生物医学工程研究,2025,44(2):125-134,10.
