生命科学研究2025，Vol.29Issue(2)：104-114,11.DOI:10.16605/j.cnki.1007-7847.2024.06.0156
ALKBH5在肿瘤和肿瘤免疫中的调控作用及相关药物研究进展
Regulatory Roles of ALKBH5 in Tumorigenesis and Tumor Immunity:Mechanisms and Drug Development
摘要
Abstract
The RNA demethylase alkB homolog 5(ALKBH5)regulates gene expression by mediating N6-me-thyladenosine(m6A)demethylation through multiple pathways of RNA metabolism.Studies have demonstrated that ALKBH5 plays a critical regulatory role in the progression of various malignancies in a m6A-dependent manner.Therefore,investigating the biological functions and mechanisms of ALKBH5 in tumors holds con-siderable importance for combating human malignancies and developing targeted therapies.This review fo-cuses on the molecular mechanisms by which ALKBH5 exerts diverse biological functions in tumors,its roles in tumor-related immunity,and ALKBH5-targeted therapeutic strategies along with their clinical implica-tions,with aiming to provide novel insights and perspectives for in-depth research on ALKBH5-mediated molecular mechanisms in tumorigenesis and development of related therapeutic agents.关键词
alkB同源物5(ALKBH5)/N6-甲基腺苷(m6A)/肿瘤/肿瘤免疫/治疗策略/药物研发Key words
alkB homolog 5(ALKBH5)/N6-methyladenosine(m6A)/tumor/tumor immunity/therapeutic stra-tegy/drug development分类
生物科学引用本文复制引用
高雨雨,熊心怡,陶怀,何迎春..ALKBH5在肿瘤和肿瘤免疫中的调控作用及相关药物研究进展[J].生命科学研究,2025,29(2):104-114,11.基金项目
湖南省自然科学基金项目(2022JJ30441) （2022JJ30441）
湖南省教育厅优秀青年项目(21B0383) （21B0383）
湖南省卫生健康委一般科研项目(202202023751) （202202023751）
长沙市自然科学基金项目(kq2202270) （kq2202270）
湖南中医药大学"十四五"一级学科基础医学建设项目(202302) （202302）
湖南中医药大学大学生创新性课题(2022-159) （2022-159）
