肠道菌群调控结肠炎相关结直肠癌进展的研究现状OA

Colorectal cancer has become the third most common cancer worldwide and the second leading cause of cancer-related deaths in recent years.Compared with sporadic colorectal cancer,colitis-associated colorectal cancer(CAC)presents an average onset age approximately 20 years earlier and a lower response to traditional treatments such as surgery,radiotherapy and chemotherapy,and is associated with a poorer prog-nosis.Recent studies have found that intestinal flora and its metabolites play an important role in the occur-rence and development of CAC.Modulation of gut microbiota through fecal microbiota transplantation or probiotics supplementation emerges as a highly promising option for CAC prevention and treatment.Herein,the roles and possible mechanisms of intestinal flora in the development of CAC were summarized,and the prospects of the cancer prevention and treatment through modulation of intestinal flora were discussed.