生命科学研究2025，Vol.29Issue(2)：115-122,8.DOI:10.16605/j.cnki.1007-7847.2024.04.0147
肠道菌群调控结肠炎相关结直肠癌进展的研究现状
Research Advances in the Role of Intestinal Flora in Regulating the Progression of Colitis-associated Colorectal Cancer
摘要
Abstract
Colorectal cancer has become the third most common cancer worldwide and the second leading cause of cancer-related deaths in recent years.Compared with sporadic colorectal cancer,colitis-associated colorectal cancer(CAC)presents an average onset age approximately 20 years earlier and a lower response to traditional treatments such as surgery,radiotherapy and chemotherapy,and is associated with a poorer prog-nosis.Recent studies have found that intestinal flora and its metabolites play an important role in the occur-rence and development of CAC.Modulation of gut microbiota through fecal microbiota transplantation or probiotics supplementation emerges as a highly promising option for CAC prevention and treatment.Herein,the roles and possible mechanisms of intestinal flora in the development of CAC were summarized,and the prospects of the cancer prevention and treatment through modulation of intestinal flora were discussed.关键词
结肠炎相关结直肠癌(CAC)/肠道菌群/益生菌/益生元/短链脂肪酸(SCFA)/粪菌移植(FMT)Key words
colitis-associated colorectal cancer(CAC)/intestinal flora/probiotic/prebiotic/short-chain fatty acid(SCFA)/fecal microbiota transplantation(FMT)分类
生物科学引用本文复制引用
文泓,杨哲,李可晴,李柏林,谭仕明,廖旻晶..肠道菌群调控结肠炎相关结直肠癌进展的研究现状[J].生命科学研究,2025,29(2):115-122,8.基金项目
湖南省自然科学基金面上项目(2023JJ30428) （2023JJ30428）
湖南省卫生健康委科研计划项目(D202302089038) （D202302089038）
2022年度湖南省大学生创新创业训练计划项目(S202210542145) （S202210542145）
