时珍国医国药2025，Vol.36Issue(9)：1651-1659,9.DOI:10.70976/j.1008-0805.SZGYGY-2025-0909
麻杏苦甘汤的急性毒性实验研究
Experimental study on acute toxicity of Maxing Kugan Decoction(麻杏苦甘汤)
摘要
Abstract
Objective To evaluate the safety of Maxing Kugan Decoction(麻杏苦甘汤,MXKGD)through acute toxicity experiments in rats and mice,providing a basis for clinical application.Methods Since the median lethal dose(LD50)of MXKGD via intragastric ad-ministration could not be determined,the maximum tolerable dose(MTD)was assessed using the highest achievable concentration and the maximum intragastric administration volume tolerable to the animals.Results The maximum concentration of MXKGD was 3.2g/mL,with the maximum intragastric volumes of 20 mL/kg for rats and 40 mL/kg for mice.Administered twice daily,the doses for rats and mice were 128 g/kg and 256 g/kg,respectively.These doses were 130.17 and 260.34 times the daily oral dose for adults(based on an average adult body weight of 60 kg).No animal deaths occurred during the experiment.Over 14 days of observation,no significant toxic reactions were observed,and there were no statistically significant differences in body weight,food intake and water consumption.Most of the serum biochemical parameters showed no significant changes,and minor deviations in individual parameters remained within normal ranges.Gross anatomy examinations on day 2 and after 14 days of recovery,as well as pathological assessments of the heart,liver,spleen,lungs,kidneys,thyroid,and reproductive system,revealed no abnormalities.Conclusion MXKGD caused no damage to ani-mals and showed no acute toxic reaction,demonstrating its safety and reliability for clinical use.These findings provide a robust founda-tion for its further development.关键词
麻杏苦甘汤/急性毒性/安全性评价/SD大鼠/ICR小鼠Key words
Maxing Kugan Decoction(麻杏苦甘汤,MXKGD)/Acute toxicity/Safety evaluation/SD rats/ICR mice分类
医药卫生引用本文复制引用
李佳庆,牛阳,南一,焦太强,周波,窦红莉..麻杏苦甘汤的急性毒性实验研究[J].时珍国医国药,2025,36(9):1651-1659,9.基金项目
国家自然科学基金区域创新发展联合基金(U20A20404) （U20A20404）
宁夏区域高发病中西医结合防治研究重点实验室开放项目(XZ2023010) （XZ2023010）
国家中医药管理局高水平中医药重点学科建设项目(zyyzdxk-2023209) （zyyzdxk-2023209）
全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号) （国中医药人教函[2022]75号）
