天津中医药大学学报2025，Vol.44Issue(5)：390-394,5.DOI:10.11656/j.issn.1673-9043.2025.05.02
龙牡清心合剂治疗儿童注意缺陷多动障碍临床疗效及安全性评价
Clinical efficacy and safety evaluation of Longmu Qingxin mixture in the treatment of children with attention deficit hyperactivity disorder
摘要
Abstract
[Objective]To evaluate the clinical efficacy and safety of Longmu Qingxin mixture in the treatment of children with attention deficit hyperactivity disorder(ADHD).[Methods]In this study,the random envelope method was employed to allocate 100 children diagnosed with ADHD into two groups:a control group and a treatment group,each comprising 50 participants.The control group received treatment with methylphenidate hydrochloride controlled-release tablets,whereas the experimental group was administered the Longmu Qingxin mixture in addition to the regimen provided to the control group.The duration of the treatment was 12 weeks.The scores of attention deficit hyperactivity disorder screening scale(SwansonNolan,and Pelham-Ⅳ rating scales,SNAP-Ⅳ),Conners' parent symptom questionnaire(PSQ)and Weiss functional impairment rating scales parent report(WFIRS-P)were compared between the two groups before and after treatment.The curative effect of traditional Chinese medicine(TCM)syndrome in the two groups was evaluated,and the safety was evaluated.[Results]1)SNAP-Ⅳ core symptom score:after 4 weeks of treatment,the treatment group had significantly lower attention deficit and hyperactivity/impulsivity scores than the control group(P＜0.05);after 12 weeks of treatment,the treatment group had significantly lower scores for attention deficit,hyperactivity/impulsivity,and oppositional defiance compared to the control group(P＜0.05).2)PSQ behavioral ability score:after 4 weeks of treatment,the treatment group had significantly lower scores for learning problems and impulsivity/hyperactivity compared to the control group(P＜0.05);after 12 weeks of treatment,the treatment group had significantly lower scores in conduct,learning,physical,mental,and impulsivity/hyperactivity problems compared to the control group(P＜0.05).3)WFIRS-P social function score:after 12 weeks of treatment,the treatment group had significantly lower scores in family,school,and life skills compared to the control group(P＜0.05).4)TCM syndrome efficacy:at the end of treatment,the total effective rate of the treatment group was 90.00％,and that of the control group was 72.00％,which was significantly better than that of the control group(P＜0.05).5)Safety evaluation:neither group of children had serious adverse reactions during or after the treatment.[Conclusion]Longmu Qingxin mixture can improve the core symptoms,behavioral ability and social function of children with ADHD,and the curative effect of TCM syndrome is significant,and the safety is good.关键词
注意缺陷多动障碍/龙牡清心合剂/临床疗效/安全性Key words
attention deficit hyperactivity disorder/Longmu Qingxin mixture/clinical efficacy/security分类
临床医学引用本文复制引用
徐彬彬,姜永红,张超群,李雪军,刘秀秀..龙牡清心合剂治疗儿童注意缺陷多动障碍临床疗效及安全性评价[J].天津中医药大学学报,2025,44(5):390-394,5.基金项目
上海市进一步加快中医药传承创新发展三年行动计划(2021年—2023年)项目[ZY(2021-2023)-0206-01] （2021年—2023年）
上海市临床重点专科建设项目(中医专业)(shslczdzk04102) （中医专业）
上海中医药大学附属龙华医院制剂临床评价项目(YW007-005). （YW007-005）
