天津中医药大学学报2025，Vol.44Issue(5)：417-425,9.DOI:10.11656/j.issn.1673-9043.2025.05.06
小青龙汤和玉屏风散"同病异治"过敏性鼻炎的网络药理学作用机制研究
Network Pharmacology-based investigation into the mechanism of"different treatment of the same disease"in treating allergic rhinitis with Xiaoqinglong Tang and Yupinfen San
摘要
Abstract
[Objective]This study employs network pharmacology to elucidate the active constituents,potential targets,and biological significance underlying the"different treatment of the same disease"approach in the management of allergic rhinitis using Xiaoqinglong Tang and Yupinfen San.[Methods]Active ingredients of Xiaoqinglong Tang and Yupinfen San were retrieved from TCMSP.Potential targets related to allergic rhinitis were obtained from databases such as GeneCards and OMIM.Cytoscape software was utilized to construct network plots for"Xiaoqinglong Tang-active ingredients-potential targets-allergic rhinitis"and"Yupinfen San-active ingredients-potential targets-allergic rhinitis."Venn diagrams illustrating key targets of the disease and drugs were generated using the STRING database and Cytoscape.Molecular docking analyses were performed using Autodock-Vina.[Results]Screening revealed that quercetin and kaempferol are common active ingredients in both Xiaoqinglong Tang and Yupinfen San.Xiaoqinglong Tang includes exclusive ingredients such as beta-sitosterol,naringenin,stigmasterol,while Yupinfen San contains unique ingredients like wogonin,7-O-methylisomucronulatol,formononetin.Potential targets like IL13,IL4R,IL4,IL5,RNASE3 are shared between Xiaoqinglong Tang and Yupinfen San.[Conclusion]Xiaoqinglong Tang and Yupinfen San exhibit noticeable differences in herb dosage and quantity.From a molecular perspective,both prescriptions share common active ingredients and feature distinct ones.This suggests that while there are similarities,there are also differences in the treatment of allergic rhinitis.This study employs network pharmacology to explore the active ingredients,potential targets,and biological significance of Xiaoqinglong Tang and Yupinfen San,providing insight into the"different treatment of the same disease"paradigm in allergic rhinitis management.关键词
小青龙汤/玉屏风散/过敏性鼻炎/同病异治/网络药理学Key words
Xiaoqinglong Tang/Yupinfen San/allergic rhinitis/different treatment of the same disease/network pharmacology分类
临床医学引用本文复制引用
李肇阳,王上,赵梦涵,董涵,袁卫玲..小青龙汤和玉屏风散"同病异治"过敏性鼻炎的网络药理学作用机制研究[J].天津中医药大学学报,2025,44(5):417-425,9.基金项目
国家自然科学基金面上项目(82174242). （82174242）
