天津中医药大学学报2025，Vol.44Issue(5)：472-480,9.DOI:10.11656/j.issn.1673-9043.2025.05.13
生物碱治疗2型糖尿病药理作用的研究进展
Research progress on the pharmacological effects of alkaloids in the treatment of type 2 diabetes mellitus
摘要
Abstract
Type 2 diabetes mellitus(T2DM)is a complex metabolic disorder with complex pathogenesis,which is prone to cause a variety of complications and seriously threatens human health.While traditional therapeutic drugs play a hypoglycemic role,most of them will produce serious side effects and induce diabetic complications,while some alkaloids with hypoglycemic effects have attracted people's attention because of their advantages of wide range of sources and low toxic side effects.At present,a large number of literature has reported that alkaloids have good hypoglycemic activity and can actively treat diabetic complications.In this paper,we summarize the representative alkaloid monomer components,such as berberine,1-deoxynojirimycin,dendrobine,matrine,etc.,and review the pharmacological mechanism of their pharmacological effects in the treatment of type 2 diabetes mellitus and its complications.In order to provide a theoretical reference for the treatment of type 2 diabetes and its complications and the development of alkaloid drugs.关键词
2型糖尿病/中药/生物碱/胰岛素抵抗/作用机制Key words
type 2 diabetes/traditional Chinese medicine/alkaloids/insulin resistance/mechanism of action分类
医药卫生引用本文复制引用
杨元娇,陈金鹏,刘毅,盖晓红,王凡凡,田成旺,张彩霞..生物碱治疗2型糖尿病药理作用的研究进展[J].天津中医药大学学报,2025,44(5):472-480,9.基金项目
国家自然科学基金青年科学基金项目(82003936). （82003936）
