现代医药卫生2025，Vol.41Issue(5)：1057-1061,1066,6.DOI:10.3969/j.issn.1009-5519.2025.05.001
利用癌症基因组图谱数据库分析miR-181a-2-3p在胃癌中的表达及预后意义
Expression and prognostic value of miR-181a-2-3p in patients with gastric carcinoma:The Cancer Gene Atlas database based study
摘要
Abstract
Objective To analyze the expression and prognostic value of microRNA-181a-2-3p(miR-181a-2-3p)in patients with gastric carcinoma(GC).Methods The Cancer Gene Atlas(TCGA)databases were selected to filtrate the demographic,clinicopathologic,survival outcomes and miRNA sequencing data of GC patients,and a total of 466 GC patients were included.Paired sample T-test was used to analyze the ex-pression difference of miR-181a-2-3p in GC tissues and adjacent tissues.The diagnostic value of miR-181a-2-3p was evaluated by drawing the working characteristic curves of subjects.Kaplan-Meier survival curve was used to compare the differences in progression-free time(PFI)and overall survival(OS)of patients with different miR-181a-2-3p expression levels.Univariate and multivariate COX regression analysis was used to screen and predict prognostic factors of PFI and OS.The function and signaling pathway enrichment of potential target genes of miR-181a-2-3p were analyzed using gene ontology and the Kyoto Encyclopedia of Genes and Ge-nomes.Results The expression level of miR-181a-2-3p in GC tissues(median was 8.70)was significantly higher than that in paracancer tissues(median was 7.97),and the difference was statistically significant(P＜0.05).miR-181a-2-3p has good diagnostic value for GC(area under ROC curve was 0.748,95％CI 0.689-0.808).Patients with high expression of miR-181a-2-3p had significantly shorter PFI(median was 25.5 months)and OS(median was 20.3 months)than those with low expression(median were 55.0 months and 42.4 months,respectively),and the differences were statistically significant(P＜0.05).miR-181a-2-3p is one of the independent prognostic factors affecting patients 'PFI and OS(HR=1.856,1.788,95％CI 1.137-3.030,1.061-3.014,P=0.013,0.029),the functions of miR-181a-2-3p target genes were mainly concentrat-ed in regulating cell death.Conclusion miR-181a-2-3p is highly expressed in GC tissues,which is closely re-lated to poor prognosis of patients and can be used as a biomarker for GC diagnosis and prognosis,and its bio-logical function is mainly related to cell death.关键词
胃肿瘤/微小RNA-181a-2-3p/预后/表达/癌症基因图谱数据库Key words
Stomach neoplasms/Micro RNA-181a-2-3p/Prognosis/Express/The Cancer Gene Atlas database分类
临床医学引用本文复制引用
王心平,郑侠,韩玉洁,姜超..利用癌症基因组图谱数据库分析miR-181a-2-3p在胃癌中的表达及预后意义[J].现代医药卫生,2025,41(5):1057-1061,1066,6.基金项目
江苏省中医药科技发展计划项目(YB201916). （YB201916）
