现代医药卫生2025，Vol.41Issue(5)：1083-1086,4.DOI:10.3969/j.issn.1009-5519.2025.05.006
基于药物治疗管理模式的绝经后骨质疏松症患者药学服务研究
Pharmaceutical care of postmenopausal osteoporosis patients based on drug therapy management model
摘要
Abstract
Objective To explore the intervention effect of pharmaceutical care based on drug therapy management model in postmenopausal osteoporosis patients.Methods A total of 110 postmenopausal pa-tients with osteoporosis admitted to this hospital from September 2021 to December 2022 were selected as the study objects,and were divided into observation group and control group according to the intervention time of pharmaceutical care,with 55 cases in each group.In the control group,the decision and implementation of drug therapy and health education were provided by regular specialists,while in the observation group,the clinical pharmacists provided pharmaceutical intervention services based on the drug therapy management model.Morisky medication Compliance Scale(MMAS-8)was used to evaluate the medication compliance of patients.The lumbar vertebral bone density of patients was measured by 3D quantitative CT(row 16 of spinal bone density)plain scan,and the changes of serum amino terminal lengthened peptide of total type 1 collagen(TPINP),osteocalcin(OSTE)and β collagen special sequences(βCL)of patients in two groups were com-pared.Results Bone mineral density(BMD)in both groups was significantly higher after treatment than be-fore treatment,and BMD in observation group was significantly higher than that in control group after treat-ment,the differences were statistically significant(P＜0.05).After treatment,the levels of TPINP and OSTE,and the score of Morisky medication compliance scale in observation group were significantly higher than those in control group,and the level of βCL was significantly lower than that in control group,with sta-tistical significance(P＜0.05).Conclusion The application of pharmaceutical care based on drug therapy management mode in the clinical treatment of postmenopausal osteoporosis patients can significantly improve the BMD of patients after treatment,improve bone metabolism,medication compliance,and the therapeutic effect of osteoporosis.关键词
药物治疗管理/骨质疏松,绝经后/药学服务/干预性研究Key words
Drug therapy management/Osteoporosis,postmenopausal/Pharmaceutical services/Intervention studies分类
临床医学引用本文复制引用
郭倩倩,王晓娟,杨庆宇,葛春丽,陈楠..基于药物治疗管理模式的绝经后骨质疏松症患者药学服务研究[J].现代医药卫生,2025,41(5):1083-1086,4.基金项目
河南省科技创新领军人才培养项目(LJRC2023017) （LJRC2023017）
河南中医药大学苗圃工程项目(MP2021-33). （MP2021-33）
