现代医药卫生2025，Vol.41Issue(5)：1090-1094,5.DOI:10.3969/j.issn.1009-5519.2025.05.008
HBV RNA在经治慢乙肝低病毒血症患者中的临床意义
Clinical significance of HBV RNA in chronic hepatitis B patients with low-level viremia after NAs treatment
摘要
Abstract
Objective To study the clinical meaning of HBV RNA in in chronic hepatitis B patients with low-level viremia(LLV)after NAs treatment.Methods A total of 185 patients with chronic hepatitis B(CHB)who were admitted to the first affiliated Hospital of Shihezi University from December 2022 to No-vember 2023 were enrolled in the study.According to the viral load,divided into LLV group(HBV DNA 30-＜2 000 IU/mL,93 cases)and complete virological response(CVR)group(HBV DNA＜30 IU/mL,92 ca-ses).The relationship between HBV DNA and HBV RNA and other serological indexes was compared be-tween the two groups,and further investigate the differences in various indicators among patients with differ-ent HBV e antigen(HBeAg)statuses in the LLV group.Results Among 185 patients,109 cases were posi-tive for HBV RNA,with a positivity rate of 58.9％,which was higher than the positivity rate of HBV DNA[50.3％(93/185)].The HBV RNA levels and positivity rates in the LLV group were significantly higher than those in the CVR group,and the differences were statistically significant(P＜0.05).There were no sig-nificant correlation between HBV DNA,HBV RNA,HBV surface antigen(HBsAg),and alanine aminotrans-ferase in the LLV group patients(P＞0.05);HBV RNA was moderately correlated with HBsAg(P＜0.001).Among the LLV group patients,54 cases were HBeAg positive,with a positivity rate of 58.1％;Among the patients in the CVR group,35 cases were positive for HBeAg,with a positivity rate of 38.0％.The serum HBV RNA of HBeAg positive patients and the levels of alanine aminotransferase in the LLV group HBsAg were significantly higher than those in negative individuals,and the differences were statistically significant(P＜0.05).HBV RNA was an independent risk factor for LLV(odds ratio=1.422,95％confi-dence interval 1.175-1.721,P＜0.001).Conclusion HBV RNA and HBsAg are correlated after LLV occurs in patients with chronic hepatitis B B after treatment.HBeAg status is a strong factor related to serum HBV RNA level.HBV RNA level is an independent risk factor for LLV.HBV RNA can be used as a biomarker to judge the HBV covalent closed loop DNA transcription activity in the liver of patients with chronic hepatitis B LLV after treatment.关键词
低病毒血症/慢性乙型肝炎/乙型肝炎病毒RNAKey words
Low-level viremia/Chronic hepatitis B/Hepatitis B virus RNA分类
临床医学引用本文复制引用
田丽艳,詹爱琴,安轶,范雪莉..HBV RNA在经治慢乙肝低病毒血症患者中的临床意义[J].现代医药卫生,2025,41(5):1090-1094,5.基金项目
新疆生产建设兵团科技计划资助项目(2024ZD071). （2024ZD071）
