现代医药卫生2025，Vol.41Issue(5)：1095-1098,4.DOI:10.3969/j.issn.1009-5519.2025.05.009
空腹血糖对老年抑郁症患者认知功能的影响
Effects of fasting blood glucose on cognitive function in late-life depression
摘要
Abstract
Objective To investigate the effects of fasting glucose on cognitive function in elderly pa-tients with depression.Methods A total of 346 elderly patients with depression treated in Shanghai Baoshan Mental Health Center from January 2021 to December 2022 were selected as the study objects,including 6 patients who did not complete scale assessment,12 patients who did not complete blood test,and 4 patients who did not complete dosimetric assessment and blood test.A total of 324 patients were included.According to the fasting blood glucose level,the patients were divided into low blood glucose group(30 cases),normal blood glucose group(210 cases)and high blood glucose group(84 cases).The differences of fasting blood glucose level and the total score of the Montreal Cognitive Assessment Scale(MoCA)among the 3 groups were compared,and the correlation between fasting blood glucose level and the total score of MoCA was ana-lyzed.Results Among 324 patients,113(34.88％)had cognitive impairment.The incidence of cognitive im-pairment in the low blood glucose group was significantly lower than that in the normal blood glucose group and the high blood glucose group,the total MoCA score was higher than that in the normal blood glucose group and the high blood glucose group,the incidence of cognitive impairment in the normal blood glucose group was significantly lower than that in the high blood glucose group,and the total MoCA score was higher than that in the high blood glucose group,with statistical significance(P＜0.05).The fasting blood glucose level was negatively correlated with the total score of MoCA in the normal blood glucose group(P＜0.05).Conclusion There is a high proportion of cognitive impairment in elderly patients with depression,and the level of fasting blood glucose has a certain impact on cognitive function in elderly patients with depression.The closer the level of fasting blood glucose is to 3.9 mmol/L in elderly patients with depression,the better the cognitive function is.关键词
血糖/老年人/抑郁症/认知Key words
Blood glucose/Aged/Depressive disorder/Cognition分类
临床医学引用本文复制引用
王晶,刘子逸,李霞..空腹血糖对老年抑郁症患者认知功能的影响[J].现代医药卫生,2025,41(5):1095-1098,4.基金项目
上海市宝山区老年抑郁障碍重点专科项目(BSZK-2023-BP10) （BSZK-2023-BP10）
上海市宝山区卫生健康系统英才培养计划项目(BSWSYX-2024-07). （BSWSYX-2024-07）
