现代医药卫生2025，Vol.41Issue(5)：1099-1102,4.DOI:10.3969/j.issn.1009-5519.2025.05.010
托法替布治疗不同背景活动性类风湿关节炎的临床观察
Efficacy of tofacitinib in the treatment of activity rheumatoid arthritis with different therapy backgrounds
摘要
Abstract
Objective To investigate the clinical efficacy of tofacitinib in treating active rheumatoid ar-thritis(RA)with different backgrounds.Methods A total of 46 RA patients admitted to the rheumatology de-partment of our hospital from July 2021 to December 2022 were selected and divided into initial treatment group and retreatment group according to different anti-rheumatism treatment methods,with 23 cases in each group.The initial treatment group was the first visit and had not received regular anti-rheumatic drug therapy before.The retreatment group was treated with a full course of treatment and a full dose of antirheumatic drugs to improve the condition but the disease remained active.All patients in both groups were given tofacatnib orally,5 mg twice a day,in combination with conventional synthetic antirheumatic drugs.The num-ber of joint pain,number of joint swelling,erythrocyte sedimentation rate,C-reactive protein,range of motion score 28,simplified disease activity index,clinical disease activity index and other changes were observed in the two groups before treatment and 1,3,6 and 12 months after treatment.Results The number of joint pain,range of motion score 28,simplified disease activity index and clinical disease activity index of the two groups were all significantly decreased 1 month after treatment compared with before treatment,and still remained ef-fective 12 months after treatment.The number of joint swelling at 3,6 and 12 months after treatment was sig-nificantly reduced compared with before treatment,with statistical significance(P＜0.05).There were no sig-nificant difference in clinical remission rate and standard treatment rate between the two groups(P＞0.05).Conclusion Tofacitinib is effective and long-lasting in the treatment of active RA with different backgrounds.The recovery time of joint swelling is longer than that of joint pain.Paid attention toclinical signs of patients is important.It is more reliable to use comprehensive evaluation index to evaluate the disease activity of pa-tients.The rate of clinical compliance of RA is high,but the rate of clinical remission is low.The treatment of RA requires the development of more long-term maintenance therapy to reduce disease recurrence.关键词
托法替布/活动性/类风湿关节炎Key words
Tofacitinib/Activity/Rheumatoid arthritis分类
医药卫生引用本文复制引用
陈家佳,钟意,漆翔宇,刘静..托法替布治疗不同背景活动性类风湿关节炎的临床观察[J].现代医药卫生,2025,41(5):1099-1102,4.基金项目
贵州省卫生健康委员会科学技术基金项目(gzwkj2023-329) （gzwkj2023-329）
贵州省遵义市科技计划项目[遵市科合HZ(2022)90号]. （2022）
