协和医学杂志2025，Vol.16Issue(3)：545-551,7.DOI:10.12290/xhyxzz.2025-0115
口腔菌群与儿童生长发育
Oral Microbiota and Childhood Growth and Development
摘要
Abstract
Childhood is a critical period for growth and development,and the oral microbiota,as the second most diverse microbial community in the human body,plays a pivotal role in maintaining children's health.Recent studies have demonstrated that dysbiosis of the oral microbiota not only contributes to oral disea-ses such as dental caries and periodontitis but may also influence the development of children's skeletal,nerv-ous,digestive,cardiovascular,and immune systems through mechanisms involving inflammatory responses,metabolic regulation,and cross-organ communication networks.This review systematically examines the role of the oral microbiota in childhood growth and development and,guided by the core principles of the"active health"model,proposes multiple intervention strategies—including probiotics,xylitol,and mouthwashes—to optimize children's health through early oral microbiota modulation.关键词
口腔健康/口腔菌群/儿童生长发育/主动健康Key words
oral health/oral microbiota/childhood growth and development/active healthcare分类
医药卫生引用本文复制引用
叶蓉蓉,杜函泽,陈适,李道伟,潘慧..口腔菌群与儿童生长发育[J].协和医学杂志,2025,16(3):545-551,7.基金项目
国家重点研发计划(2022YFC3600203) National Key Research and Development Program of China(2022YFC3600203) （2022YFC3600203）
