协和医学杂志2025，Vol.16Issue(3)：577-583,7.DOI:10.12290/xhyxzz.2024-0747
青春期青少年维生素D营养状况与胰岛素抵抗的相关性:横断面观察性研究
Association Between Vitamin D Status and Insulin Resistance in Adolescents:A Cross-sectional Observational Study
摘要
Abstract
Objective To investigate the correlation between vitamin D nutritional status and insulin re-sistance in pubertal adolescents.Methods This cross-sectional observational study employed convenience sam-pling to recruit 2021-grade(8th grade)students from Jining No.7 Middle School in Shandong Province on June 5,2023.Data collection included questionnaires,physical examinations,and imaging assessments to ob-tain general information,secondary sexual characteristics development,and bone age.Venous blood samples were collected to measure fasting blood glucose(FBG),fasting insulin(FINS),homeostasis model assessment of insulin resistance(HOMA-IR),and 25-hydroxyvitamin D[25(OH)D]levels.Spearman correlation analysis and multivariate linear regression models were used to examine the associations between ser-um vitamin D levels and FBG,FINS,and HOMA-IR.Results The study included 168 pubertal adolescents[69 females(41.1％),99 males(58.9％);mean age(13.27±0.46)years].All participants had entered puberty based on sexual development assessment.Vitamin D deficiency was observed in 41 participants(24.4％),insufficiency in 109(64.9％),and sufficiency in 18(10.7％).The median HOMA-IR was 3.49(2.57,5.14).Significant differences were found across vitamin D status groups for HOMA-IR[4.45(2.54,6.62)vs.3.58(2.74,5.13)vs.2.25(1.62,3.40),P=0.003]and FINS[21.5(13.4,30.1)mU/L vs.16.5(13.0,23.9)mU/L vs.11.2(8.3,17.8)mU/L,P=0.006],showing decreasing trends with improving vitamin D status.Spearman analysis revealed significant inverse correlations between serum 25(OH)D levels and FBG(r=-0.171,P=0.027),FINS(r=-0.234,P=0.002),and HOMA-IR(r=-0.250,P=0.001).After adjusting for age,sex,body mass index,and daily outdoor activity time,multivariate linear re-gression demonstrated that log-transformed 25(OH)D levels were independently and inversely associated with FBG(β=-0.324,P=0.022),lnFINS(β=-0.241,P=0.048),and lnHOMA-IR(β=-0.312,P=0.017).Conclusions Vitamin D deficiency/insufficiency is prevalent among pubertal adolescents,and serum vitamin D levels show a significant inverse association with insulin resistance.These findings suggest the poten-tial importance of vitamin D status in metabolic health during puberty.关键词
维生素D/胰岛素抵抗/青少年/青春期Key words
vitamin D/insulin resistance/adolescents/puberty分类
医药卫生引用本文复制引用
郭晓湲,杨凯,阳洪波,杜函泽,潘慧,汪雨彤,周智博,陈适,张梅,班博,李萍,张欣冉,张秋平..青春期青少年维生素D营养状况与胰岛素抵抗的相关性:横断面观察性研究[J].协和医学杂志,2025,16(3):577-583,7.基金项目
国家重点研发计划(2022YFC3600202,2022YFC3600203) National Key Research and Development Program(2022YFC3600202,2022YFC3600203) （2022YFC3600202,2022YFC3600203）
