协和医学杂志2025，Vol.16Issue(3)：584-590,7.DOI:10.12290/xhyxzz.2025-0125
维生素D在青少年运动与甘油三酯关联中的中介效应:前瞻性横断面研究
The Mediating Effect of Vitamin D on the Association Between Exercise and Triglyceride in Adolescents:A Prospective Cross-sectional Study
摘要
Abstract
Objective To investigate the mediating role of vitamin D in the association between exercise and triglyceride among adolescents,as well as its potential molecular mechanisms.Methods This prospective cross-sectional study utilized convenience sampling,enrolling 2021-grade students from Jining No.7 Middle School on June 5,2023.Moderate-intensity exercise frequency was assessed via standardized questionnaires,serum 25-hydroxyvitamin D levels were measured using chemiluminescence,and triglyceride levels were deter-mined via fully automated biochemical analysis.Spearman's rank correlation analysis was employed to examine the relationships among moderate-intensity exercise,triglyceride,and vitamin D.A mediation model was constructed using the Baron&Kenny causal steps approach,adjusting for confounders including age,sex,body mass index(BMI),dairy intake,sweet food consumption,and fast-food intake.Subgroup analyses were performed based on BMI.The significance of the mediation effect was confirmed using both the Bootstrap and Sobel tests.Results A total of 354 adolescents meeting the inclusion criteria were enrolled,including 142 females(40.11％)and 212 males(59.89％),with a median age of 13.25(12.83,13.83)years.Spearman's analysis revealed a significant negative correlation between moderate-intensity exercise and triglyceride levels(r=-0.21,P＜0.001),a signifi-cant negative correlation between vitamin D and triglyceride(r=-0.30,P＜0.001),and a significant positive correlation between moderate-intensity exercise and vitamin D levels(r=0.26,P＜0.001).The mediation model indicated that vitamin D partially mediated the triglyceride-lowering effect of exercise(52.22％,95％CI:-0.027 to-0.009,P＜0.001),with the effect remaining significant after confounder adjustment(47.83％,95％CI:-0.019 to-0.005).Subgroup analysis showed that in adolescents with BMI＜24 kg/m2,vitamin D accounted for 82.01％of the mediation effect between exercise and triglyceride(95％CI:-0.022 to-0.005,P=0.005),which remained significant after adjustment(81.20％,95％CI:-0.022 to-0.005,P=0.005).In contrast,among adolescents with BMI ≥ 24 kg/m2,the mediation effect was nonsignificant before(3.38％,95％CI:-0.014 to 0.009,P=0.760)and after adjustment(7.51％,95％CI:-0.019 to 0.012,P=0.621).Conclusions Vitamin D serves as a key mediator in the triglyceride-lowering effect of exercise among adoles-cents,independent of age,sex,and dietary habits.This mediation effect is particularly pronounced in adolescents with BMI＜24 kg/m2.The underlying mechanism may involve vitamin D-regulated lipid metabolism-related gene expression and suppression of inflammatory pathways,suggesting that targeting vitamin D signaling could be a po-tential molecular strategy for early intervention in adolescent dyslipidemia.关键词
维生素D/运动/甘油三酯/中介效应/青少年Key words
vitamin D/exercise/triglycerides/mediating effect/adolescent分类
社会科学引用本文复制引用
黄箔钏,郭晓湲,汪雨彤,刘佳轩,潘慧,陈适..维生素D在青少年运动与甘油三酯关联中的中介效应:前瞻性横断面研究[J].协和医学杂志,2025,16(3):584-590,7.基金项目
国家重点研发计划(2022YFC3600202) National Key Research and Development Program of China(2022YFC3600202) （2022YFC3600202）
