协和医学杂志2025，Vol.16Issue(3)：641-646,6.DOI:10.12290/xhyxzz.2025-0147
生长激素治疗先天性心脏病合并身材矮小患儿初步疗效:6例病例报告并文献复习
Preliminary Efficacy of Growth Hormone Therapy in Children With Congenital Heart Disease and Short Stature:A Six-case Report and Literature Review
摘要
Abstract
Congenital heart disease(CHD)is a congenital malformation resulting from abnormal embryonic development of the heart and great vessels,accounting for approximately 25％of all congenital malformations.Children with CHD are often complicated by short stature.Although surgical treatment can improve their growth and development to a certain extent,some children still experience growth retardation after surgery.Recombinant human growth hormone(rhGH)is the main drug for treating short stature,but its efficacy and safety in the treatment of patients with concomitant CHD warrant further investigation.This article reports six cases of children with CHD and short stature who were treated with rhGH.Through a literature review,we summarize and discuss the therapeutic efficacy,follow-up experiences,and adverse reactions of rhGH treatment,aiming to pro-vide references for clinicians in applying rhGH to treat patients with CHD and short stature.关键词
先天性心脏病/身材矮小/重组人生长激素/生长迟缓/先天性畸形Key words
congenital heart disease/short stature/recombinant human growth hormone/growth retardation/congenital malformation分类
临床医学引用本文复制引用
杨曦,梁思宇,李茜茜,杜函泽,宋帅华,姜悦,马慧娟,陈适,潘慧..生长激素治疗先天性心脏病合并身材矮小患儿初步疗效:6例病例报告并文献复习[J].协和医学杂志,2025,16(3):641-646,6.基金项目
河北省卫生健康委医学科学研究课题(20250358) Hebei Provincial Health Commission Medical Science Research Project(20250358) （20250358）
