摘要
Abstract
Objective To explore the correlation between human body fat distribution and carotid athero-sclerosis.Methods Adult healthy individuals who underwent physical examinations at the Health Management Center of the International Medical Department(Xidan Campus)of Peking Union Medical College Hospital be-tween January 2020 and January 2023 were selected as study participants.Baseline data,laboratory indicators,Inbody body composition analysis,and carotid ultrasound examination results were collected.Participants were divided into carotid atherosclerosis group and control group based on carotid ultrasound examination results.Baseline data,laboratory indicators,and body composition differences between the two groups were compared,and multivariate Logistic regression analysis was conducted to investigate the correlation between carotid athero-sclerosis and body composition.To further explore the correlation between fat distribution and carotid atheroscle-rosis,the ratio of trunk fat to limb fat(trunk fat/limb fat),visceral fat area,and waist-to-hip ratio were strati-fied into Q1,Q2,Q3,and Q4 groups(with Q1 group as the reference)based on quartiles(Q1 to Q4),and a forest plot was constructed to analyze the risk of carotid atherosclerosis in each subgroup.Results A total of 2221 participants were included in this study,including 1194 males(53.76％)and 1027 females(46.24％),with a mean age of(50.28±10.93)years.There were 1049 cases in the carotid atherosclerosis group and 1172 cases in the control group.Baseline data analysis showed that the carotid atherosclerosis group had a higher age and male proportion compared to the control group(both P＜0.001).The carotid atherosclero-sis group also had significantly higher levels of body weight,body mass index(BMI),waist-to-hip ratio,body fat mass,trunk fat,trunk fat/limb fat,and visceral fat area compared to the control group(all P＜0.05).La-boratory test results indicated that the carotid atherosclerosis group had significantly higher levels of blood glu-cose,glycated hemoglobin,triglycerides,and uric acid compared to the control group(all P＜0.001).Multi-variate Logistic regression analysis revealed that after adjusting for age,gender,smoking history,and drinking history,trunk fat,trunk fat/limb fat,and waist-to-hip ratio were significantly associated with the risk of carotid atherosclerosis(both P＜0.05).Compared with the Q1 group,the Q4 group had a significantly increased risk of atherosclerosis(OR=1.81,95％CI:1.26-2.61,P＜0.05).However,there were no significant correla-tions between waist-to-hip ratio,visceral fat area,and carotid atherosclerosis(P＞0.05).Conclusions There is a significant correlation between trunk fat/limb fat and the occurrence of carotid atherosclerosis.In the future,the sample size should be expanded,and more precise methods for measuring fat distribution should be adopted to validate the conclusions of this study.关键词
脂肪分布/颈动脉粥样硬化/躯干脂肪/四肢脂肪/腰臀比/内脏脂肪面积Key words
fat distribution/carotid atherosclerosis/trunk fat/limb fat/waist-to-hip ratio/visceral fat area分类
医药卫生
