协和医学杂志2025，Vol.16Issue(3)：722-729,8.DOI:10.12290/xhyxzz.2024-0543
NLRP3炎症小体与细胞焦亡在糖尿病肾病中的作用机制研究进展
Research Pogress on Action Mechanism of NLRP3 Inflammasome and Pyroptosis in Diabetic Nephropathy
摘要
Abstract
Diabetic nephropathy(DN),as one of the most common complications of diabetes,is a primary cause of end-stage renal disease.The pathogenesis of DN encompasses processes such as chronic in-flammation,recruitment and activation of immune cells,tubular and glomerular injury,and renal fibrosis.These processes are highly correlated with the activation of the nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3(NLRP3)inflammasome and the resulting pyroptosis it mediates.Previous studies have shown that the release of pro-inflammatory cytokines,leakage of damage-associated molecular patterns(DAMPs),recruitment and activation of immune cells can be reduced by regulating the NLRP3 in-flammasome and its mediated pyroptosis,thereby slowing the diffusion of inflammatory responses in adjacent cells,fibrosis,and tissue remodeling processes.Ultimately,these process can improve renal injury and dys-function caused by diabetic nephropathy.This article summarizes the molecular regulatory mechanisms of the NLRP3 inflammasome and its mediated pyroptosis at different pathological stages of DN,proposes potential targets for regulating their activation,aiming to provide a new direction for personalized treatment of DN.关键词
糖尿病肾病/NLRP3炎症小体/细胞焦亡/免疫激活/作用机制Key words
diabetic nephropathy/NLRP3 inflammasome/pyroptosis/immune activation/mechanism of action分类
医药卫生引用本文复制引用
雷震云,薛国忠,刘臻华,张新丽..NLRP3炎症小体与细胞焦亡在糖尿病肾病中的作用机制研究进展[J].协和医学杂志,2025,16(3):722-729,8.基金项目
国家自然科学基金地区项目(82160865) （82160865）
甘肃中医药大学附属医院院内科研基金项目(gzfy-2021-06) Regional Project of National Natural Science Foundation of China(82160865) （gzfy-2021-06）
Hospital Scientific Research Fund Project of the Affiliated Hospital of Gansu University of Traditional Chinese Medicine(gzfy-2021-06) （gzfy-2021-06）
