协和医学杂志2025，Vol.16Issue(3)：730-738,9.DOI:10.12290/xhyxzz.2024-0258
双特异性磷酸酶在糖尿病肾病中的研究进展
Research Progress of Dual-Specificity Phosphatase in Diabetic Nephropathy
摘要
Abstract
Diabetic nephropathy(DN),a prevalent microvascular complication of diabetes,has emerged as a leading cause of end-stage renal disease worldwide.Recent studies on the dual-specific phospha-tase(DUSP)family have revealed a significant reduction in DUSP expression levels in renal disease,sugges-ting that enhancing its expression may mitigate or alleviate the symptoms associated with renal disease.The pri-mary function of DUSP is to mediate the dephosphorylation of mitogen-activated protein kinase(MAPK),which effectively inhibits the activation of the MAPK pathway,thus playing a crucial regulatory role in the onset and progression of DN.This article aims to investigate the correlation between DN and DUSP and to summarize the current research advancements concerning DUSP in the context of DN,providing new insights and essential the-oretical foundations for its diagnosis and treatment.关键词
糖尿病肾病/丝裂原活化蛋白激酶/双特异性磷酸酶/丝裂原活化蛋白激酶磷酸酶Key words
diabetic nephropathy/mitogen-activated protein kinase/dual-specificity phosphatase/mitogen-activated protein kinase phosphatase分类
医药卫生引用本文复制引用
王小年,敖其,黄海,列才华..双特异性磷酸酶在糖尿病肾病中的研究进展[J].协和医学杂志,2025,16(3):730-738,9.基金项目
新疆维吾尔自治区自然科学基金(2023D01C95) Natural Science Foundation of Xinjiang Uygur Autonomous Region(2023D01C95) （2023D01C95）
