畜牧兽医杂志2025，Vol.44Issue(3)：1-9,9.DOI:10.7606/j.issn.1004-6704.2025.03.001
基于Agricultural Animal Omics Database(AAOD)数据库挖掘绵羊GDF9基因变异
Exploration of Mutations of Sheep GDF9 Gene based on Agricultural Animal Omics Database(AAOD)Database
摘要
Abstract
Currently,the application of big data and omics databases has become crucial for enhancing sheep reproductive performance in industry development.The Growth Differentiation Factor 9(GDF9)gene plays a vital role in follicular develop-ment,ovulation rate,and lambing number,serving as one of the major genes determining sheep prolificacy.Although some key mutation sites are associated with lambing numbers,identifying all potential genetic variations of GDF9 in sheep remains unre-solved.In recent years,Prof.Jiang Yu's team at Northwest A&F University developed the Agricultural Animal Omics Data-base(AAOD),which integrates global public data and high-depth genomic information from Chinese indigenous sheep breeds.This database contains genetic variants(SNPs and InDels),epige-netic markers,and phenotype association data across over 50 breeds,with monthly updates.Based on AAOD,this study aimed to mine GDF9 gene variants in sheep and systemati-cally investigate its molecular structure,expression patterns,enrichment analysis,and novel fertility-related mutations.These findings will identify novel potential functional sites of GDF9 in sheep reproduction,providing new targets for gene editing technologies and establishing a theoretical foundation for genetic improvement strategies to enhance sheep repro-ductive efficiency.关键词
绵羊/GDF9基因/Agricultural Animal Omics Database(AAOD)数据库/单核苷酸多态性/插入缺失Key words
sheep/GDF9 gene/Agricultural Animal Omics Database(AAOD)database/SNP/InDels分类
畜牧业引用本文复制引用
潘晔君,刘耿,潘传英,张清峰,蓝贤勇..基于Agricultural Animal Omics Database(AAOD)数据库挖掘绵羊GDF9基因变异[J].畜牧兽医杂志,2025,44(3):1-9,9.基金项目
科技创新2030-农业生物育种重大项目(2022ZD-040130207) （2022ZD-040130207）
