畜牧兽医杂志2025，Vol.44Issue(3)：20-25,6.DOI:10.7606/j.issn.1004-6704.2025.03.003
基于全基因组数据绘制全球绵羊LCORL基因SNP变异图谱
A SNPs Variation Map of LCORL Gene among Global Sheep Breeds Based on Whole-genome Resequencing
摘要
Abstract
The LCORL gene is an important gene that influences the growth rate and body size of sheep.Constructing a com-prehensive genetic variation map of this gene will help systematically assess its correlation with sheep growth traits and identify growth-related variation sites.However,no study has systematically screened the single nucleotide polymorphisms(SNPs)of this gene in different sheep breeds.In this study,based on whole-genome resequencing data from 1 615 sheep across 27 domestic and international breeds,4 777 high-confidence SNPs were identified,including 16 mutations in coding regions,with 10 missense mutations and 6 synonymous mutations.Additionally,this study found that one missense mutation(g.38075364G＞A)is under selection in large-bodied Dorper sheep,suggesting that this site may be related to sheep growth traits.This study constructed a genetic variation map of the LCORL gene in sheep,providing valuable resources for exploring mutations and genetic markers related to sheep growth traits.关键词
绵羊/LCORL基因/SNP/全基因组重测序Key words
sheep/LCORL gene/SNP/whole-genome se-quencing分类
畜牧业引用本文复制引用
张新月,张硕,王海燕,霍永智,刘小东,姜雨,李冉..基于全基因组数据绘制全球绵羊LCORL基因SNP变异图谱[J].畜牧兽医杂志,2025,44(3):20-25,6.基金项目
农业生物育种国家科技重大专项(2022ZD04-01403) （2022ZD04-01403）
陕西省双链融合项目(2022GD-TSLD-46-0401) （2022GD-TSLD-46-0401）
陕西省自然科学基金(2023-JC-YB-157) （2023-JC-YB-157）
陕西省重点研发计划(2024NC2-GJHX-15) （2024NC2-GJHX-15）
