医学新知2025，Vol.35Issue(5)：588-596,9.DOI:10.12173/j.issn.1004-5511.202410036
癌症相关成纤维细胞在恶性肿瘤中的研究进展
Research progress on cancer-associated fibroblasts in malignant tumors
摘要
Abstract
Cancer-associated fibroblasts(CAFs)are key components of the tumor micro environment(TME)and play an essential role in the development of tumors.It is suggested that CAFs influence tumor cell proliferation,invasion and migration as well as regulate tumor cell resistance to chemotherapeutic agents through the secretion of cytokines,chemokines,growth factors and extracellular matrix proteins.And they also enhance the immune escape ability of tumors by interacting with tumor-associated immune cells.This article comprehensively expounds how the biomarkers and subtypes of CAFs can promote the development of malignant tumors by affecting the immune escape of tumor cells and TME,and discusses the mechanism and potential treatment strategies of CAFs in malignant tumors.关键词
癌症相关成纤维细胞/肿瘤微环境/上皮-间质转化/免疫逃逸/靶向治疗Key words
Cancer-associated fibroblasts/Tumor microenvironment/Epithelial-mesenchymal transition/Immune escape/Targeted therapy分类
医药卫生引用本文复制引用
杜予馨,乌日罕,刘彩霞..癌症相关成纤维细胞在恶性肿瘤中的研究进展[J].医学新知,2025,35(5):588-596,9.基金项目
内蒙古医科大学重点学科临床医学-肿瘤多学科综合体系建设项目(DC2300000607) （DC2300000607）
内蒙古自治区"草原英才"工程创新创业团队项目 （）
内蒙自治区高校科研一般项目(NJZY23154) （NJZY23154）
内蒙古医科大学附属医院青年骨干项目(2022NYFYFG010) （2022NYFYFG010）
