医药导报2025，Vol.44Issue(6)：862-867,6.DOI:10.3870/j.issn.1004-0781.2025.06.004
基于改善脑代谢药物不良反应的适药新物态研究进展
Research Progress of New Substance Status of the Applicable Drug Based on Adverse Reactions of Brain Metabolites
摘要
Abstract
The drugs used to improve brain metabolism mainly include ergotamine derivatives,GABA derivatives,vitamin B6 derivatives,neuropeptides,morpholines,hormones and other.However,these drugs may have adverse reactions during clinical application.This article focuses on the adverse effects of commonly used drugs for brain metabolism,and reviews the studies on the new state of pharmaceutical substances,such as drug combination,chiral resolution of isomers,crystal form of dominant drugs,co-crystal drugs and nanodrugs,with the aim of reducing adverse reactions.By summarizing the research on modifying the solid state of drugs to mitigate adverse reactions,this article provides new research insights for obtaining new drug with less adverse reaction and greater clinical value.关键词
脑代谢药物/药品不良反应/适药新物态/晶型/共晶Key words
Brain metabolism drugs/Adverse drugs effects/New state for pharmaceuticalsubstance/Polymorphicdrugs/Co-crystal drugs分类
药学引用本文复制引用
王文文,贾艳潇,闫明,杨德智,高莉,张丽,吕扬..基于改善脑代谢药物不良反应的适药新物态研究进展[J].医药导报,2025,44(6):862-867,6.基金项目
基金资助新疆维吾尔自治区重点实验室开放课题(2023D04065) （2023D04065）
中国医学科学院医学与健康科技创新工程重大协同创新项目(2022-I2M-1-015) （2022-I2M-1-015）
山东省重点研发计划(2021ZDSYS26) （2021ZDSYS26）
新疆维吾尔自治区2023年"天池英才"项目. （）
