医药导报2025，Vol.44Issue(6)：867-873,7.DOI:10.3870/j.issn.1004-0781.2025.06.005
共晶技术改善非洛地平稳定性及体外溶出度
Enhanced Dissolution Behavior and Stability of Felodipine by Cocrystal Technology
摘要
Abstract
Objective To develop four novel cocrystals of felodipine aimed at improving its poor solubility.Methods Felodipine-caproamide,felodipine-2,4-dihydroxybenzoic acid,felodipine-2,5-dihydroxybenzoic acid,and felodipine-3,5-dihydroxybenzoic acid cocrystals were prepared using the slurry method.The cocrystals were characterized by powder X-ray diffraction(PXRD),differential scanning calorimetry(DSC),thermogravimetric analysis(TGA),and Fourier-transform infrared spectroscopy(FT-IR).Stability tests and in vitro dissolution studies were conducted to assess their pharmaceutical properties.Results All four cocrystals demonstrated improved solubility and dissolution rates compared to pure felodipine.Notably,the felodipine-3,5-dihydroxybenzoic acid cocrystal showed superior stability and a marked increase in solubility.Conclusion Cocrystallization technology significantly enhanced the stability and dissolution profile of felodipine,underscoring its potential for pharmaceutical formulation development.关键词
非洛地平/共晶/晶体工程/溶出度/溶出速率Key words
Felodipine/Cocrystal/Crystal engineering/Dissolution degree/Dissolution rate分类
药学引用本文复制引用
邹瑶,孟欣,刘梅菊,邢逞,龚宁波,吕扬..共晶技术改善非洛地平稳定性及体外溶出度[J].医药导报,2025,44(6):867-873,7.基金项目
北京市自然科学基金资助项目(7222261) （7222261）
中国医学科学院医学与健康科技创新工程资助项目(2022-I2M-01-015). （2022-I2M-01-015）
