医药导报2025，Vol.44Issue(6)：874-881,8.DOI:10.3870/j.issn.1004-0781.2025.06.006
质子泵抑制剂的适药新物态研究进展
Research Progress of New State of Pharmaceutical Substance of the Proton Pump Inhibitors
摘要
Abstract
Currently,the first-generation of proton pump inhibitors(PPIs)commonly utilized in clinical practice for the treatment of peptic ulcer include omeprazole,lansoprazole,and pantoprazole,and the second generation include rabeprazole and esomeprazole.The predominant mode of PPI administration is oral,which poses numerous challenges in clinical settings owing to their poor solubility,susceptibility to gastric acid degradation,short half-life,and limited stability.This article presents a comprehensive review of studies exploring the novel states of these five PPIs,include polymorphism,co-crystal drugs,and nanodrugs.Furthermore,it summarizes the advancements in research aimed at modifying the physicochemical properties of these drugs through innovative solid states,thereby enhancing their bioavailability and stability.This work offers a new perspective for researchers endeavoring to develop new states of pharmaceutical substances that incorporate PPIs.关键词
质子泵抑制剂/适药新物态/晶型/共晶/纳米药物Key words
Proton pump inhibitors/New state of pharmaceutical substance/Polymorphism/Co-crystal/Nanomedicine分类
药学引用本文复制引用
胡堃,王文文,邢逞,高肇林,张丽,吕扬..质子泵抑制剂的适药新物态研究进展[J].医药导报,2025,44(6):874-881,8.基金项目
基金资助山东省重点研发计划项目(2021ZDSYS26) （2021ZDSYS26）
第四届滕州英才专项 （）
枣庄市自主创新及成果转化计划(重大科技创新工程项目)(2022GH15) （重大科技创新工程项目）
中国医学科学院医学与健康科技创新工程重大协同创新项目(2022-I2M-1-015) （2022-I2M-1-015）
新疆维吾尔自治区重点实验室开放课题(2023D04065) （2023D04065）
新疆维吾尔自治区2023年天池英才项目. （）
