医药导报2025，Vol.44Issue(6)：881-885,5.DOI:10.3870/j.issn.1004-0781.2025.06.007
雌二醇及其衍生物类药物固体形态的研究进展
Research Progress on the Solid Form of Estradiol and Its Derivatives
摘要
Abstract
Solid forms,such as polymorphs and co-crystals,can improve the physicochemical properties of drugs without changing their molecular structure,increasing their solubility,bioavailability,stability,and thus affecting their original pharmacodynamic activity.Estradiol and its derivatives ethinylestradiol and estriol,contain steroidal parent nucleus,which results in a very low water solubility.Researches showed that polymorphism and co-crystal studies could enhance the water solubility of estradiol and its derivatives.This paper reviews the research progress on the solid forms of estradiol and its derivatives in last decade.关键词
雌二醇/炔雌醇/雌三醇/固体形态/多晶型/共晶Key words
Estradiol/Ethinylestradiol/Estriol/Solid form/Polymorphism/Co-crystal分类
药学引用本文复制引用
徐娟,陈晓锋,宁丽峰..雌二醇及其衍生物类药物固体形态的研究进展[J].医药导报,2025,44(6):881-885,5.基金项目
中央级公益性科研院所基本科研业务费专项(2022GJZ06). （2022GJZ06）
