医药导报2025，Vol.44Issue(6)：886-893,8.DOI:10.3870/j.issn.1004-0781.2025.06.008
共晶技术在手性药物拆分中的研究进展
Research Progress of CocrystalTechnology in Chiral Drug Resolution
摘要
Abstract
In recent years,the demand for single enantiomer drugs has gradually increased,and the separation technology of chiral drugs has also been developed rapidly.In this article,we summarized the application and progress of cocrystal technology in chiral drug resolution,focusing on the existence forms of cocrystal former formations(single compound molecules,ions,and claths),the common preparation methods of cocrystal resolution,the physical and chemical factors affecting the resolution efficiency(co-formed chirality,solvent system,temperature)and the computer-aided prediction method of chiral cocrystal in the process of chiral drug resolution,to provide a reference for related research on chiral resolution using cocrystal technology.关键词
共晶/手性药物/手性拆分/对映异构体Key words
Cocrystal/Chiral drugs/Chiral resolution/Enantiomer分类
药学引用本文复制引用
高雨涵,陶月,苟恒铭,张宝喜,张丽,杨世颖,吕扬..共晶技术在手性药物拆分中的研究进展[J].医药导报,2025,44(6):886-893,8.基金项目
新疆维吾尔自治区重点实验室开放课题(2023D04035) （2023D04035）
中国医学科学院医学与健康科技创新工程(2021-I2M-1-029). （2021-I2M-1-029）
