医药导报2025，Vol.44Issue(6)：900-905,6.DOI:10.3870/j.issn.1004-0781.2025.06.010
热熔挤出联合3D打印技术开发布洛芬药物共晶新制剂
Hot Melt Extrusion Coupled with 3D Printing Technology in the Development of Ibuprofen Pharmaceutical Cocrystal Preparation
摘要
Abstract
Objective To explore the development of new formulations new pharmaceutical cocrystal by combining hot melt extrusion and 3D printing technologies.Methods The insoluble drug ibuprofen and nicotinamide were selected as model drugs,and hot melt extrusion was applied to extrude ibuprofen-nicotinamide cocrystal by regulating the processing temperature,screw speed and residence time,etc.Hot-stage polarized light microscopy,powder X-ray diffraction,differential scanning calorimetry,Fourier transform infrared spectroscopy,and Raman spectroscopy were used for characterization analysis.The process research was carried out by investigating properties such as eutectic particle size and distribution,angle of repose,and vibrational solidity density.On this basis,two 3D printing techniques,fused deposition molding and selective laser sintering type,were selected for pharmaceutical cocrystal loaded sheet printing.Results A new formulation of pharmaceutical cocrystal tablets loaded with ibuprofen-nicotinamide was successfully printed through the combined application of hot-melt extrusion and 3D printing technologies.Conclusions Combined process of hot melt extrusion and 3D printing technology in the field of developing new pharmaceutical cocrystal formulations,laying the material foundation and scientific support for the development of new pharmaceutical cocrystal formulations with personalized and programmable release on demand.关键词
药物共晶/热熔挤出/结构表征/3D打印Key words
Pharmaceutical cocrystal/Hot melt extrusion/Structural characterization/3D printing分类
药学引用本文复制引用
于铭超,李雪,倪雯,张家祥..热熔挤出联合3D打印技术开发布洛芬药物共晶新制剂[J].医药导报,2025,44(6):900-905,6.基金项目
青岛市自然科学基金原创探索项目(23-2-1-184-zyyd-jch) （23-2-1-184-zyyd-jch）
泰山学者工程资助项目(tsqn202211297) （tsqn202211297）
山东省自然科学基金青年项目(ZR202211080049). （ZR202211080049）
