医药导报2025，Vol.44Issue(6)：912-917,6.DOI:10.3870/j.issn.1004-0781.2025.06.012
CGRP/CGRPR抗体药物作用机制及应用研究进展
Advances in Mechanistic and Translational Applications of Anti-CGRP/CGRP Receptor Antibodies
摘要
Abstract
Calcitonin gene-related peptides(CGRP)are peptides that are ubiquitous in the central and peripheral nervous systems,which has been shown to be associated with pain,setting off a boom in the development of chemical small molecule antagonists targeting CGRP receptors,but most of them have failed due to greater hepatotoxicity.Anti-CGRP/CGRPR antibodies have attracted widespread attention due to their high specificity and safety,especially lower hepatotoxicity.This article reviews the structure and function of CGRP and its receptors,as well as the research progress of anti-CGRP-related neutralizing antibodies in order to provide a reference for the exploration of disease mechanisms and drug development related to CGRP.关键词
降钙素基因相关肽/降钙素基因相关肽受体/抗体药物Key words
Calcitonin gene-related peptide/Calcitonin gene-related peptide receptor/Antibodies分类
药学引用本文复制引用
邢聪,彭峰浩,乔春霞,吕梦蝶..CGRP/CGRPR抗体药物作用机制及应用研究进展[J].医药导报,2025,44(6):912-917,6.基金项目
国家自然科学基金资助项目(31771010) （31771010）
河南省重点研发与推广专项科技攻关项目(232102310020). （232102310020）
