医药导报2025，Vol.44Issue(6)：923-927,5.DOI:10.3870/j.issn.1004-0781.2025.06.014
不同释药机制盐酸二甲双胍缓释片研究进展
Research Progress on Metformin Hydrochloride Sustained-release Tablets with Different Drug Release Mechanisms
摘要
Abstract
Objective Metformin hydrochloride is recommended as the first-line,first choice,basic and whole course drug for the treatment of type 2 diabetes by various domestic and international guidelines because of its safety,effectiveness,economy and other characteristics.In order to solve the problems of large blood glucose fluctuations,multiple daily medications,and gastrointestinal adverse reactions of traditional ordinary tablets,sustained-release tablets with various drug release mechanisms have been developed and applied in clinical practice,which led to the innovation and breakthrough of pharmaceutical technology.And the product provided better therapeutic efficacy and safety.Among them,the third-generation gastric floating sustained-release tablets may be more suitable for metformin hydrochloride absorbed in the upper digestive tract,which is expected to further improve drug tolerance and provide better choices for patients with type 2 diabetes.This article reviewed the research progress of metformin hydrochloride sustained-release tablets from the aspects of product launch history,drug release mechanism,and clinical trials.关键词
盐酸二甲双胍/缓释片/释药机制Key words
Metformin hydrochloride/Sustained-release tablets/Drug release mechanism分类
医药卫生引用本文复制引用
尹明星,王文清..不同释药机制盐酸二甲双胍缓释片研究进展[J].医药导报,2025,44(6):923-927,5.基金项目
国家自然科学基金青年科学基金资助项目(82404585). （82404585）
