医药导报2025，Vol.44Issue(6)：949-954,6.DOI:10.3870/j.issn.1004-0781.2025.06.018
2型糖尿病患者认知功能与用药依从性的相关性
Correlation Between Cognitive Function and Medication Compliance in Patients with Type 2 Diabetes Mellitus
摘要
Abstract
Objective To investigate the correlation between cognitive function and medication compliance in patients with type 2 diabetes mellitus(T2DM).Methods Patients with T2DM who were admitted to the Department of Endocrinology,Drum Tower Hospital,Nanjing University School of Medicine from July 2023 to December 2023 were selected.The clinical data and laboratory results of the patients were collected.The medication compliance of the patients was evaluated by Adherence to Refills and Medications Scales(ARMS).And the overall cognitive function and independent cognitive domain tests were performed.According to the diagnostic criteria of mild cognitive impairment(MCI),patients were divided into normal cognitive group and MCI group.Linear regression analysis was used to evaluate the correlation between cognitive function and medication compliance in T2DM patients.Multivariate logistic regression analysis was used to explore the relationship between cognitive dysfunction and poor medication compliance in T2DM patients.Results A total of 216 patients with T2DM were enrolled,including 113 patients with normal cognitive function and 103 patients with MCI.The ARMS score(16.4±4.1 vs.15.1±2.8)and the rate of poor medication compliance(54.4%vs.31.0%)in the MCI group were higher than those in the normal cognitive group(all P<0.05).After adjusting for gender,age,years of education and glycosylated hemoglobin,ARMS scores were significantly negatively correlated with immediate memory,attention and delayed memory scores(all P<0.05).Multivariate logistic regression analysis showed that patients with MCI had a higher risk of poor medication adherence[OR=2.645,95%CI=(1.414,4.946),P<0.001].Conclusions Poor cognitive function,especially memory and concentration,is associated with reduced medication compliance in patients with T2DM.Patients with memory and attention problems should be given appropriate medication advice to improve their compliance in clinical practice.关键词
2型糖尿病/认知功能/用药依从性Key words
Type 2 diabetes mellitus/Cognitive function/Medication compliance分类
医药卫生引用本文复制引用
翟贝贝,张洲,杨思珏,李方怡,朱文慧,毕艳..2型糖尿病患者认知功能与用药依从性的相关性[J].医药导报,2025,44(6):949-954,6.基金项目
南京鼓楼医院临床研究专项资金资助项目(2022-LCYJ-ZD-03,2022-LCYJ-PY-02). （2022-LCYJ-ZD-03,2022-LCYJ-PY-02）
