医药导报2025，Vol.44Issue(6)：973-977,5.DOI:10.3870/j.issn.1004-0781.2025.06.022
艾加莫德治疗吉兰-巴雷综合征的超说明书用药管理
Administration of Off-label Drug Uses of Efgartigimod in the Treatment of Guillain-Barré Syndrome
摘要
Abstract
Objective To analyze and intervene in typical cases of off-label drug uses of efgartigimod in the treatment of Guillain-Barré syndrome,and to provide further medication strategies for the management of Guillain-Barré syndrome.Methods By reviewing the treatment of two cases of Guillain-Barré syndrome,where intravenous immunoglobulin was ineffective or the blood product supply was limited,the clinical pharmacist conducted an evidence-based evaluation of the off-label drug uses of efgartigimod for the treatment of Guillain-Barré syndrome following guidelines and norms,provided assistance to the physician in developing a treatment regimen(10 mg·kg-1 once a week for 4 weeks),and closely monitored and evaluated the medication administration process.Results Two patients had significant improvement and no serious adverse events after treatment with efgartigimod.Clinical pharmacists play an important role in the decision-making,regulation and monitoring of off-label drug uses,ensuring the safety and rationality of medication use.Conclusion Clinical pharmacists should actively involved in the practice of off-label drug uses and make a contribution to the promotion of rational clinical use of medication.关键词
艾加莫德/吉兰-巴雷综合征/药物治疗管理/超说明书用药Key words
Efgartigimod/Guillain-Barré syndrome/Medication therapy management/Off-label drug use分类
医药卫生引用本文复制引用
蒋啸,汤柳,郑雪丹..艾加莫德治疗吉兰-巴雷综合征的超说明书用药管理[J].医药导报,2025,44(6):973-977,5.基金项目
湖北省自然科学基金科研项目(2023AFB239) （2023AFB239）
湖北省高等教育学会教育科研课题(2024XD216) （2024XD216）
湖北省重点实验室开放项目(2023KFZZ015). （2023KFZZ015）
