中国动物检疫2025，Vol.42Issue(4)：1-7,7.DOI:10.3969/j.issn.1005-944X.2025.04.001
我国基因Ⅻ型新城疫病毒基因组特性
Genomic Characterization of Newcastle Disease Virus Genotype Ⅻ in China
摘要
Abstract
The genome sequences of 4 representative strains of Newcastle disease virus(NDV)genotype Ⅻ isolated in China from 2019 to 2022 were analyzed in the study.The results showed that all the sequences had a full length of 15 192 nt and their F protein cleavage sites were 112RRQKR/F117,conforming to the characteristics of virulent strain;the nucleotide sequence homology of the 4 strains ranged from 97.0％to 99.3％,and was the highest identical to representative genotype Ⅻ strain(90.1％-90.3％),then to other genotype strains(80.5％-89.2％);the strains presented multiple amino acid variations in the signal peptide region,fusion peptide region,heptapeptide repeat region and transmembrane region of F and HN proteins;and genetic evolution analysis based on F gene indicated that all the 4 strains belonged to genotype Ⅻ.2.The genomic characteristics of NDV genotype Ⅻ in China were analyzed in the study,laying a foundation for the development of effective prevention and control strategies.关键词
新城疫病毒/基因Ⅻ型/氨基酸变异/遗传进化分析Key words
NDV/genotype Ⅻ/amino acid variation/genetic evolutionary analysis分类
畜牧业引用本文复制引用
丁雨,王海鸣,陈璐,于晓慧,张昕悦,刘玉峰,朱明慧,王静静,刘华雷..我国基因Ⅻ型新城疫病毒基因组特性[J].中国动物检疫,2025,42(4):1-7,7.基金项目
国家重点研发计划项目(2022YFD1800600) （2022YFD1800600）
