中国动物检疫2025，Vol.42Issue(5)：86-92,7.DOI:10.3969/j.issn.1005-944X.2025.05.015
猪肺炎支原体的免疫逃逸机制
Immune Escape Mechanism of Mycoplasma hyopneumoniae
岳巧灵 1王翠芳 1王桂英2
作者信息
- 1. 阳谷县畜牧兽医事业发展中心,山东阳谷 252300
- 2. 聊城大学,山东 聊城 252800
- 折叠
摘要
Abstract
Mycoplasma hyopneumoniae(Mhp),a pathogen of enzootic pneumonia(EP),is widely prevalent around the world,posing huge economic losses to global pig industry.To clarify the complex interaction between Mhp and immune system is conducive to better understanding its molecular mechanism of immune escape.However,it has been still in suspense.Long-term chronic infection and persistent lung colonization will be usually caused by the invasion of Mhp,indicating an effective immune escape mechanism.The capacity of Mhp to change its surface antigens is endowed by gene mutation and post-translational protein processing,and cell invasion may be achieved by Mhp with the help of adhesins to regulate host immune system through inducing inflammation,incomplete autophagy,apoptosis and inhibiting the activity of immune cells or immune effectors.In the paper,research results on the immune escape mechanism of Mhp were systematically summarized,the mechanism was elaborated in detail,and recommendations on treatment of Mhp infection and development of new vaccines were proposed,aiming to provide a reference for effective prevention and control of the disease and for development of new vaccines.关键词
猪肺炎支原体/免疫逃逸/免疫系统/分子机制Key words
Mycoplasma hyopneumoniae/immune evasion/immune system/molecular mechanism分类
畜牧业引用本文复制引用
岳巧灵,王翠芳,王桂英..猪肺炎支原体的免疫逃逸机制[J].中国动物检疫,2025,42(5):86-92,7.
