中国临床药学杂志2025，Vol.34Issue(5)：344-349,6.DOI:10.19577/j.1007-4406.2025.05.004
抗菌药物相关性脑病的临床特征分析
Clinical feature analysis of antibiotic-associated encephalopathy
摘要
Abstract
AIM To analyze the occurrence patterns and clinical characteristics of antibiotic-associated encephalopathy and provide a basis for prevention,early identification,and treatment of antibiotic-associated encephalopathy.METHODS A retrospective analysis was conducted on 77 patients of antibiotic-associated encephalopathy that occurred during hospitalization from January 2021 to January 2024.The clinical factors were analyzed including patients' age,gender,medication details,clinical manifestations,interventions,and outcomes.RESULTS Among the 77 patients with antibiotic-associated encephalopathy,50 were males(64.94％)and 27 were females(35.06％),aged between 20 and 89 years,with an average age of(77.52±7.07)years.Specifically,41 patients aged between 80 and 89 years were accounting for the largest proportion(53.25％).Cephalosporins(54.55％)were the main antibiotics that caused encephalopathy.Clinical manifestations of encephalopathy primarily included hallucination,restlessness,lethargy,apathy,gibberish,hyperexcitability,and involuntary limb-shaking.The average time of occurrence of neuropsychiatric symptoms was(5.23±2.50)days after using antibiotics,most of which occurred in 4-6 days(accounting for 42.86％).Most of the symptoms disappeared within 1-3 days after drug withdrawal or dose reduction(accounting for 66.23％).Therapeutic drug monitoring was performed in 42 patients,with 38.10％(16/42)demonstrating elevated serum antibiotic concentrations.CONCLUSION Attention should be paid to the occurrence of antibiotic-associated encephalopathy,prevention,early identification,and treatment.Efforts should be made to enhance the monitoring of antibiotics drug concentrations in the blood to reduce the risk of adverse reactions.关键词
抗菌药物相关性脑病/抗菌药物/临床特征/药品不良反应Key words
antibiotic-associated encephalopathy/antibiotics/clinical manifestations/adverse drug reactions分类
药学引用本文复制引用
彭佳,李昕,刘丽华,李美云,陈沈珏..抗菌药物相关性脑病的临床特征分析[J].中国临床药学杂志,2025,34(5):344-349,6.基金项目
抗耐药微生物药物湖南省重点实验室基金资助项目(编号2023TP1013) （编号2023TP1013）
湖南省感染性疾病临床合理用药技术示范基地基金资助项目(编号2016SK4008) （编号2016SK4008）
长沙市2024年科技计划项目(编号kzd2401051) （编号kzd2401051）
