中国实验动物学报2025，Vol.33Issue(4)：540-548,9.DOI:10.3969/j.issn.1005-4847.2025.04.008
茶花蜜对高脂饮食果蝇模型生物学特征的影响
Impact of camellia honey on high-fat diet-induced intestinal inflammation and injury in Drosophila
摘要
Abstract
Objective To explore the effects of camellia honey on intestinal inflammation and injury induced by a high-fat diet(HFD)in Drosophila.Methods A HFD model group of fruit flies was created by feeding with standard culture medium containing 30％lard.Each camellia honey groups were fed the same high-fat medium containing different concentrations of camellia honey.The body mass,eclosion rate,climbing ability,size of lipid droplets,and levels of intestinal reactive oxygen species in adult flies were measured and analyzed.Results Compared with the model group,each camellia honey groups showed significant improvements.Specifically,camellia honey ameliorated the following HFD-induced alterations:decline in eclosion rate,increase in pupal volume,increase in adult average body mass,decrease in adult climbing ability,enlargement of the lipid droplet area,elevation in intestinal ROS levels,and intestinal damage.Conclusions Camellia honey improved the growth and development,intestinal inflammation,and injury induced by a HFD in Drosophila.关键词
茶花蜜/肠道/高脂饮食/果蝇/生物表型Key words
camellia honey/intestine/high-fat diet/Drosophila/bio-phenotype分类
生物学引用本文复制引用
章俐俐,曹淑琼,徐梦婷,洪滔,张美芳,刘丹,罗涛,刘志勇..茶花蜜对高脂饮食果蝇模型生物学特征的影响[J].中国实验动物学报,2025,33(4):540-548,9.基金项目
江西中医药大学大学生创新创业项目(2024125),校级科技创新团队发展计划(CXTD-22004).Funded by Jiangxi University of Traditional Chinese Medicine Undergraduate Innovation and Entrepreneurship Project(2024125),University-Level Scientific and Technological Innovation Team Development Program(CXTD-22004). （2024125）
