中国实验动物学报2025，Vol.33Issue(4)：549-560,12.DOI:10.3969/j.issn.1005-4847.2025.04.009
基于数据挖掘的肺纤维化动物模型特点分析
Data mining analysis of animal models of pulmonary fibrosis
摘要
Abstract
Objective To study the characteristics of animal models of pulmonary fibrosis so as to provide a reference for the standardization of such models,and to guide research on the pathogenesis,diagnosis,and treatment of pulmonary fibrosis.Methods Studies using experimental pulmonary fibrosis in animals published in the past 10 years were retrieved from the CNKI,Wanfang,VIP,SinoMed,and PubMed databases.Factors including animal species,sex,modeling method,and detection index were summarized,and the data were analyzed using Excel.Results A total of 292 eligible studies were included.The animals mainly included SD rats,Wistar rats,and C57BL/6 mice,and most were male.The most common modeling drugs were bleomycin,paraquat,and silica suspension,mainly administered by intratracheal injection,with a typical modeling cycle of 28 d.The detection indexes mainly comprised lung tissue pathology and measurements of protein expression,cytokine levels,and biochemical indexes.Conclusions SD rats and C57BL/6 mice were the most commonly used animals for experimental pulmonary fibrosis,and intratracheal injection of bleomycin(5 mg/kg)was the most frequently used modeling method.This approach allows for the straightforward and effective replication of pathological features resembling human pulmonary fibrosis,and may serve as a reference for future experimental studies using animal models of pulmonary fibrosis.关键词
肺纤维化/动物模型/数据挖掘/发病机制/基础研究Key words
pulmonary fibrosis/animal model/data mining/pathogenesis/basic research分类
生物学引用本文复制引用
曾茵,李琳琳,马祥铭,肖雨锋,胡珏..基于数据挖掘的肺纤维化动物模型特点分析[J].中国实验动物学报,2025,33(4):549-560,12.基金项目
2021年度湖南省教育厅科学研究项目(21B0360),湖南中医药大学2021年度科研基金项目(2021XJJJ019),湖南中医药大学2020年度中西医结合一流学科开放基金项目(2020ZXYJH13),湖南中医药大学2023年本科生科研创新基金项目(57),湖南中医药大学2024年大学生创新训练项目(233).Funded by the 2021 Scientific Research Project of the Hunan Provincial Education Department(21B0360),the 2021 Scientific Research Fund Project of Hunan University of Chinese Medicine(2021XJJJ019),the 2020 Open Fund Project for First-Class Discipline of Integrated Traditional Chinese and Western Medicine of Hunan University of Chinese Medicine(2020ZXYJH13),the 2023 College Student Scientific Research and Innovation Fund Project of Hunan University of Chinese Medicine(57),the 2024 College Student Innovation Training Project of Hunan University of Chinese Medicine(233). （21B0360）
