中国比较医学杂志2025，Vol.35Issue(4)：97-103,7.DOI:10.3969/j.issn.1671-7856.2025.04.010
神经纤毛蛋白-1在动脉粥样硬化中的作用机制研究进展
Research progress on mechanisms of neuropilin-1 in atherosclerosis
摘要
Abstract
Atherosclerosis is the main pathological basis of coronary heart disease,and is thus of great importance in terms of the prevention and treatment of coronary heart disease.Neuropilin-1(NRP1),a member of the neuropilin receptor family,is closely associated with various growth factors,including vascular endothelial growth factor(VEGF)and transforming growth factor-β(TGF-β).NRP1 influences the progression of atherosclerosis through its crucial roles in angiogenesis and inflammatory responses,and sensing of wall shear stress on the vascular endothelium.This review thus explores the mechanisms underlying the role of NRP1 in atherosclerosis and the development of NRP1-targeted therapeutic strategies,to provide new insights into the diagnosis and treatment of atherosclerosis.关键词
动脉粥样硬化/神经纤毛蛋白-1/血管内皮生长因子/转化生长因子β/壁面剪切应力Key words
atherosclerosis/neuropilin-1/vascular endothelial growth factor/transforming growth factor-beta/wall shear stress分类
医药卫生引用本文复制引用
张心仪,蔡宏文..神经纤毛蛋白-1在动脉粥样硬化中的作用机制研究进展[J].中国比较医学杂志,2025,35(4):97-103,7.基金项目
国家自然科学基金面上项目(81973579). （81973579）
