中国比较医学杂志2025，Vol.35Issue(4)：135-149,15.DOI:10.3969/j.issn.1671-7856.2025.04.013
基于肺动脉高压的肺血管丛状病变的鼠类模型的研究进展
Progress in murine models of pulmonary vascular plexiform lesions of pulmonary arterial hypertension
摘要
Abstract
The need for suitable interventions for progressive pulmonary vascular lesions has become a bottleneck and a consequent focus in the prevention and treatment of clinical pulmonary hypertension.Plexiform lesions in pulmonary arterioles are the typical pathological manifestation of irreversible abnormal pulmonary vascular remodeling and the criterion for stage Ⅳ pulmonary vascular remodeling.There is currently no effective clinical intervention for such pathophysiological lesions,highlighting the need for corresponding animal models.This review considers new progress in the stereology of plexiform lesions and highlights plexiform-lesion models in mice and rats induced by multifactor stimulation,such as two-hit models and genetic engineering.It also evaluates the characteristics and applications of these models to provide a reference for animal experimental studies and to clarify the mechanism of pulmonary hypertension with pulmonary vascular plexiform lesions.关键词
小鼠/大鼠/肺血管丛状病变/复合刺激模型/基因工程技术模型Key words
mouse/rat/pulmonary vascular plexiform disease/multifactor stimulation model/genetic engineering technology model引用本文复制引用
李新雨,任周新,赵鹏..基于肺动脉高压的肺血管丛状病变的鼠类模型的研究进展[J].中国比较医学杂志,2025,35(4):135-149,15.基金项目
河南省高校科技创新人才支持计划(24HASTIT073) （24HASTIT073）
河南省科技研发计划联合基金项目(22301420070) （22301420070）
河南省高等学校重点科研项目(24A360013). （24A360013）
