中国比较医学杂志2025，Vol.35Issue(4)：150-158,9.DOI:10.3969/j.issn.1671-7856.2025.04.015
铁死亡介导急性白血病的机制研究进展
Research progress on the mechanism of acute leukemia mediated by ferroptosis
摘要
Abstract
Ferroptosis is closely related to iron metabolism,lipid metabolism,and amino acid metabolism,which contribute to the production of reactive oxygen species,mitochondrial damage,and cell death.Ferroptosis has recently been recognized as a key regulatory mechanism during tumor development,including in acute leukemia.This review considers the inhibitory effects of drugs on the occurrence and development of acute leukemia,by regulating key proteins or factors involved in the above three metabolic pathways of ferroptosis and by interfering with the production of lipid peroxides.We also point out the deficiencies in current research and describe the role of ferroptosis in acute leukemia.The application of these findings in clinical trials will provide new ideas for future research and the treatment of leukemia.关键词
铁死亡/急性白血病/活性氧/脂质过氧化物Key words
ferroptosis/acute leukemia/ROS/LPO引用本文复制引用
朱大诚,刘燕,魏佳旭..铁死亡介导急性白血病的机制研究进展[J].中国比较医学杂志,2025,35(4):150-158,9.基金项目
江西中医药大学中西医结合一级学科(江西省双一流学科)(zxyylxk20220103). （江西省双一流学科）
