中国比较医学杂志2025，Vol.35Issue(4)：159-168,10.DOI:10.3969/j.issn.1671-7856.2025.04.016
TRIM13在内质网质量控制中的作用及其与疾病的关系
Role of TRIM13 in endoplasmic reticulum quality control and its association with diseases
杨世英 1戎玉莹 1董玥宏 1蒋丽娜1
作者信息
- 1. 河北北方学院医学检验学院免疫教研室,河北 张家口 075000||河北北方学院微循环研究所,河北 张家口 075000
- 折叠
摘要
Abstract
The endoplasmic reticulum quality control(ERQC)system is a core mechanism for maintaining cellular homeostasis,which primarily mediates the degradation of misfolded proteins in the endoplasmic reticulum(ER)through the ER-associated degradation(ERAD)and ER autophagy(ER-phagy)pathways.Tripartite motif 13(TRIM13)is a protein located on the ER membrane,which plays a critical role in ERAD via its E3 ubiquitin ligase activity.TRIM13 also acts as a non-classical ER-phagy receptor to mediate the occurrence of ER-phagy.TRIM13 has recently received extensive attention in the field of ERQC.Here we review the structure and function of TRIM 13 and the mechanisms by which it contributes to ERQC,and summarize its abnormal expression and regulatory role in diseases,with the aim of providing new strategies for the treatment of related diseases.关键词
TRIM13/内质网质量控制/内质网相关降解/内质网自噬Key words
tripartite motif 13/endoplasmic reticulum quality control/endoplasmic reticulum-associated degradation/endoplasmic reticulum autophagy引用本文复制引用
杨世英,戎玉莹,董玥宏,蒋丽娜..TRIM13在内质网质量控制中的作用及其与疾病的关系[J].中国比较医学杂志,2025,35(4):159-168,10.
