中国实用内科杂志2025，Vol.45Issue(4)：273-278,288,7.DOI:10.19538/j.nk2025040103
十二指肠黏膜重塑:肠道功能优化与糖脂代谢调控的新视角
Duodenal mucosal resurfacing:a new perspective on gut function optimization and the regulation of glucose and lipid metabolism
摘要
Abstract
In China,over 40 million individuals with a lean or normal body type are facing the challenges of type 2 diabetes mellitus(T2DM).Duodenal mucosal resurfacing(DMR),as a bridge between surgical and pharmacological treatments,demonstrates significant potential in blood glucose control and metabolic improvement.This study aims to comprehensively review the role of DMR in regulating gut-derived hormones,gut microbiota ecology,and glucose-lipid metabolism,exploring its potential in optimizing gut function and improving metabolic health.By analyzing from multiple perspectives,including the regulation of glucose-lipid metabolism by gut-derived hormones,changes in gut microbiota homeostasis,and the mechanisms of DMR,this article reviews existing clinical studies and animal experimental data obtained by the research team.The findings indicate that although DMR does not directly regulate the secretion of gut-derived hormones,it significantly modulates the composition of gut microbiota and may indirectly promote the improvement of glucose-lipid metabolism through the enhancement of gut microbiota ecology.However,current clinical studies still face challenges such as small sample sizes and insufficient exploration of underlying mechanisms.Therefore,future research should validate the specific effects of DMR on gut microbiota and metabolic health through larger-scale clinical trials and animal models,providing new options for diabetes treatment.关键词
2型糖尿病/十二指肠黏膜重塑术/肠源性激素/肠道菌群/糖脂代谢Key words
type 2 diabetes/duodenal mucosal resurfacing/gut-derived hormones/gut microbiota/glucose and lipid metabolism分类
临床医学引用本文复制引用
周博军,王思奇,李政奇,周彪,孟化..十二指肠黏膜重塑:肠道功能优化与糖脂代谢调控的新视角[J].中国实用内科杂志,2025,45(4):273-278,288,7.基金项目
中日友好医院中央高水平医院临床科研业务费(2023-NHLHCRF-YYPP-TS-02,2023-NHLHCRF-YS-0103) （2023-NHLHCRF-YYPP-TS-02,2023-NHLHCRF-YS-0103）
国家自然科学基金面上项目(82470857) （82470857）
北京市自然科学基金面上项目(7242125) （7242125）
北京市研究型病房建设临床研究项目(2022-YJXBF-03-02) （2022-YJXBF-03-02）
